Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51924
Title: Efficacy study of novel diamidine compounds in a trypanosoma evansi goat model
Authors: Gillingwater, Kirsten
Gutierrez, Carlos 
Bridges, Arlene
Wu, Huali
Deborggraeve, Stijn
Ali Ekangu, Rosine
Kumar, Arvind
Ismail, Mohamed
Boykin, David
Brun, Reto
Keywords: Infection
Camels
Issue Date: 2011
Journal: PLoS ONE 
Abstract: Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi experimentally infected goats was investigated. A toxicity assessment and pharmacokinetic analysis of these compounds were additionally carried out. Goats demonstrated no signs of acute toxicity, when treated with four doses of 1 mg/kg/day total dose 4 mg/kg). Complete curative efficacy of experimentally infected goats was seen in the positive control group treated with diminazene at 5 mg/kg and in the DB 75 and DB 867 groups treated at 2.5 mg/kg. Drug treatment was administered once every second day for a total of seven days. Complete cure was also seen in the group of goats treated with DB 75 at 1.25 mg/kg. DB 1192 was incapable of curing goats at either four-times 2.5 mg/kg or 1.25 mg/kg. Pharmacokinetic analysis clearly demonstrated that the treatment failures of DB 1192 were due to sub-therapeutic compound levels in goat plasma, whilst compound levels for DB 75 and DB 867 remained well within the therapeutic window. In conclusion, two diamidine compounds DB 75 and DB 867) presented comparable efficacy at lower doses than the standard drug diminazene and could be considered as potential clinical candidates against T. evansi infection.
URI: http://hdl.handle.net/10553/51924
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0020836
Source: Plos One[ISSN 1932-6203],v. 6 (6)
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

7
checked on May 9, 2021

WEB OF SCIENCETM
Citations

7
checked on Jan 31, 2021

Page view(s)

6
checked on May 10, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.