Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51393
Title: A comprehensive mapping of the structure and gene organisation in the sheep MHC class I region
Authors: Siva Subramaniam, N.
Morgan, E. F.
Wetherall, J. D.
Stear, M. J. 
Groth, D. M.
Keywords: Major histocompatibility complex (MHC)
MHC class I
Sheep
Mapping
Issue Date: 2015
Journal: BMC Genomics 
Abstract: The major histocompatibility complex (MHC) is a chromosomal region that regulates immune responsiveness in vertebrates. This region is one of the most important for disease resistance because it has been associated with resistance or susceptibility to a wide variety of diseases and because the MHC often accounts for more of the variance than other loci. Selective breeding for disease resistance is becoming increasingly common in livestock industries, and it is important to determine how this will influence MHC polymorphism and resistance to diseases that are not targeted for selection. However, in sheep the order and sequence of the protein coding genes is controversial. Yet this information is needed to determine precisely how the MHC influences resistance and susceptibility to disease.
URI: http://hdl.handle.net/10553/51393
ISSN: 1471-2164
DOI: 10.1186/s12864-015-1992-4
Source: BMC Genomics [1471-2164],v. 16 (810)
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