Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51327
Title: Field trial of a combined vaccine against caprine contagious agalactia: Humoral immune response in lactating goats
Authors: de la Fe, Christian
Assunção, Patricia
Saavedra, Pedro
Ramirez, Ana 
Poveda, Jose B. 
Keywords: Subsp Mycoides Lc
Mycoplasma-Agalactiae
Sds-Page
Variability
Proteins, et al
Issue Date: 2007
Publisher: 1090-0233
Journal: Veterinary Journal 
Abstract: Two vaccines against Mycoplasina agalactiae and Mycoplasma mycoides subsp. mycoides (large colony type) were developed using inactivated strains selected in previous characterization studies. Formaldehyde and phenol were used as the inactivating agents for vaccines A and B, respectively. Aluminium hydroxide plus purified saponin (Quil-A) were added to both vaccines as adjuvant. The field trial was designed to evaluate the specific humoral immune response to the two mycoplasma species in lactating goats over a period of 7 months. The vaccines were tested on 120 goats randomly assigned to three groups of 40 animals each. Two groups received two injections of vaccine A or B respectively, and a third group remained in the herd as control. Antibody titres determined by ELISA indicated a significant difference between both vaccines and the control group over a 6-month period. Immunoblotting assays also revealed the production of antibodies against the two mycoplasma species. Further field trials are underway to evaluate the efficacy and protection conferred to the animals by these specific antibodies. (c) 2006 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10553/51327
ISSN: 1090-0233
DOI: 10.1016/j.tvjl.2006.10.021
Source: Veterinary Journal[ISSN 1090-0233],v. 174 (3), p. 610-615
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