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Title: Activities of six different quinolones against clinical respiratory isolates of streptococcus pneumoniae with reduced susceptibility to ciprofloxacin in Spain
Authors: Pérez-Trallero, E.
García-Rey, C.
Martín-Sánchez, A. M. 
Aguilar, L.
García-De-Lomas, J.
Ruiz, J.
Larruskain, J.
Bouza, E.
Cercenado, E.
Barrón, J.
López, L.
Jiménez de Anta, T.
Marco, F.
Perea, E.
Martínez, L.
Latorre, C.
Gené, A.
García-Rodriguez, J. A.
Trujillano, I.
Baquero, F.
García, A.
García, S.
Güeni, M.
Simarro, E.
García-Riestra, C.
Regueiro, B.
Jato, A.
Prieto, M.
Rubio, C.
García, C.
De la Rosa, M.
Cañas, F.
Romero, D.
González, M.
Nogueira, J. M.
Casal, M.
Ibarra, A.
Gobernado, M.
Diosdado, N.
Prats, G.
Sánchez, F.
Cisterna, R.
Morla, A.
Gómez-García, A. C.
Blanco-Palenciano, F. J.
Fenoll, A.
Casal, J.
Granizo, J. J.
Gimeno, C.
Martín, J. E.
Dal-Ré, R.
UNESCO Clasification: 32 Ciencias médicas
320806 Quimioterapia
2414 Microbiología
Keywords: Quinolones
Streptococcus pneumoniae
Issue Date: 2002
Journal: Antimicrobial Agents and Chemotherapy 
Abstract: Six quinolones were tested on 817 consecutive pneumococcal isolates for which ciprofloxacin MICs were high (≥2 μg/ml); the isolates had been collected during two recent Spanish surveillance studies. For strains for which the ciprofloxacin MIC was ≥4 μg/ml, the MICs at which 90% of the isolates tested against gemifloxacin, moxifloxacin, gatifloxacin, sparfloxacin, levofloxacin, and ofloxacin were inhibited were 0.25, 1, 1, 1, 4 and 16 μg/ml, respectively, and the corresponding prevalences of resistance were 0, 1, 4.5, 9.5, 8.4 and 23%. The proportion of isolates for which the ciprofloxacin MIC is high has increased over time.
ISSN: 0066-4804
DOI: 10.1128/AAC.46.8.2665-2667.2002
Source: Antimicrobial Agents and Chemotherapy[ISSN 0066-4804],v. 46, p. 2665-2667 8agosto 2002)
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