|Title:||Activities of six different quinolones against clinical respiratory isolates of streptococcus pneumoniae with reduced susceptibility to ciprofloxacin in Spain||Authors:||Pérez-Trallero, E.
Martín-Sánchez, A. M.
Jiménez de Anta, T.
García-Rodriguez, J. A.
De la Rosa, M.
Nogueira, J. M.
Gómez-García, A. C.
Blanco-Palenciano, F. J.
Granizo, J. J.
Martín, J. E.
|UNESCO Clasification:||32 Ciencias médicas
|Issue Date:||2002||Journal:||Antimicrobial Agents and Chemotherapy||Abstract:||Six quinolones were tested on 817 consecutive pneumococcal isolates for which ciprofloxacin MICs were high (≥2 μg/ml); the isolates had been collected during two recent Spanish surveillance studies. For strains for which the ciprofloxacin MIC was ≥4 μg/ml, the MICs at which 90% of the isolates tested against gemifloxacin, moxifloxacin, gatifloxacin, sparfloxacin, levofloxacin, and ofloxacin were inhibited were 0.25, 1, 1, 1, 4 and 16 μg/ml, respectively, and the corresponding prevalences of resistance were 0, 1, 4.5, 9.5, 8.4 and 23%. The proportion of isolates for which the ciprofloxacin MIC is high has increased over time.||URI:||http://hdl.handle.net/10553/51276||ISSN:||0066-4804||DOI:||10.1128/AAC.46.8.2665-2667.2002||Source:||Antimicrobial Agents and Chemotherapy[ISSN 0066-4804],v. 46, p. 2665-2667 8agosto 2002)|
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