Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/51270
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dc.contributor.authorPérez-Trallero, Emilioen_US
dc.contributor.authorGarcía-De-La-Fuente, Celiaen_US
dc.contributor.authorGarcía-Rey, Césaren_US
dc.contributor.authorBaquero, Fernandoen_US
dc.contributor.authorAguilar, Lorenzoen_US
dc.contributor.authorDal-Ré, Rafaelen_US
dc.contributor.authorGarcía-De-Lomas, Juanen_US
dc.contributor.authorAusina, Vicenteen_US
dc.contributor.authorDiosdado, Nievesen_US
dc.contributor.authorLópez-Hontangas, Jose L.en_US
dc.contributor.authorBarrón, Jorgeen_US
dc.contributor.authorVilar, Begoñaen_US
dc.contributor.authorMarco, Francescen_US
dc.contributor.authorJiménez-De-Anta, María T.en_US
dc.contributor.authorRomero, Doloresen_US
dc.contributor.authorGonzález-Rodríguez, Manuelen_US
dc.contributor.authorCasal, Manuelen_US
dc.contributor.authorIbarra, Anaen_US
dc.contributor.authorLatorre, Cristinaen_US
dc.contributor.authorGené, Amadeoen_US
dc.contributor.authorDe-La-Rosa, Manuelen_US
dc.contributor.authorMartínez-Brocal, Antonioen_US
dc.contributor.authorCalbo, Luisen_US
dc.contributor.authorAlados, Juan C.en_US
dc.contributor.authorMartín-Sánchez, Antonio M.en_US
dc.contributor.authorCañas, Fernandoen_US
dc.contributor.authorBouza, Emilioen_US
dc.contributor.authorCercenado, Emiliaen_US
dc.contributor.authorGarcía-Perea, Adelaen_US
dc.contributor.authorLozano, Anaen_US
dc.contributor.authorCantón, Rafaelen_US
dc.contributor.authorFenoll, Asunciónen_US
dc.contributor.authorPinedo, Alfonsoen_US
dc.contributor.authorSánchez-Bernal, María A.en_US
dc.contributor.authorRuiz, Joaquínen_US
dc.contributor.authorSimarro, Encarnaciónen_US
dc.contributor.authorAlomar, Pedroen_US
dc.contributor.authorPérez, Jose L.en_US
dc.contributor.authorGarcía-Rodríguez, Jose A.en_US
dc.contributor.authorTrujillano, Ignacioen_US
dc.contributor.authorMarimón, Jose M.en_US
dc.contributor.authorBurgada, Antoniaen_US
dc.contributor.authorGarcía-Riestra, Carlosen_US
dc.contributor.authorGarcía-Regueiro, Benitoen_US
dc.contributor.authorPerea, Evelioen_US
dc.contributor.authorNogueira, Jose M.en_US
dc.contributor.authorGobernado, Miguelen_US
dc.contributor.authorEsteban, Encarnaciónen_US
dc.contributor.authorLerma, Mercedesen_US
dc.contributor.authorLandínez, Ricardoen_US
dc.contributor.authorTejero, Doloresen_US
dc.contributor.authorTorres, Julioen_US
dc.contributor.authorVasallo, Francisco J.en_US
dc.contributor.authorRubio, Carmenen_US
dc.date.accessioned2018-11-24T23:03:11Z-
dc.date.available2018-11-24T23:03:11Z-
dc.date.issued2005en_US
dc.identifier.issn0066-4804en_US
dc.identifier.urihttp://hdl.handle.net/10553/51270-
dc.description.abstractA multicenter susceptibility surveillance (the S.A.U.C.E. project) including 2,721 Streptococcus pneumoniae, 3,174 Streptococcus pyogenes, and 2,645 Haemophilus influenzae consecutive isolates was carried out in 25 hospitals all over Spain from November 2001 to October 2002 to evaluate the current epidemiology of resistance of the main bacteria involved in community-acquired respiratory tract infections. Susceptibility testing was performed in a single centralized laboratory by a broth microdilution method. The prevalence of resistant S. pneumoniae strains was 0.4% for cefotaxime, 4.4% for amoxicillin and amoxicillin-clavulanic acid, 25.6% for cefuroxime-axetil, 34.5% for erythromycin, clarithromycin, and azithromycin, and 36.0% for cefaclor. Phenotypes of resistance to erythromycin were MLSB (macrolide-lincosamide-streptogramin B) in 89.9% (gene ermB) and M (macrolide) in 9.7% of cases (gene mefA). No strain harbored both genes simultaneously. Serotypes 19, 6, 23, 14, and 3 were the most prevalent, accounting for 54.6% of the total isolates. Resistance to macrolides seems to be the most alarming point, since among penicillin-susceptible isolates it reached 15.1% compared to 55.8% among penicillin-resistant strains. Geographically, a number of regions had rates of erythromycin resistance above 40% (even higher in children). Resistance to erythromycin was also high in S. pyogenes isolates: mean regional 33.2%, beta-lactamase-producing H. influenzae were 20%, whereas 4.4% had a beta-lactamase-negative, ampicillin-resistant phenotype. We highlight the importance of different geographical frequencies of coresistance (associations of resistance to different drugs within the same species) and coupled resistance (association of resistance between different species) probably resulting from different local coselective events.en_US
dc.languageengen_US
dc.relation.ispartofAntimicrobial Agents and Chemotherapyen_US
dc.sourceAntimicrobial Agents and Chemotherapy[ISSN 0066-4804],v. 49, p. 1965-1972en_US
dc.subject32 Ciencias médicasen_US
dc.subject320103 Microbiología clínicaen_US
dc.subject.otherAntimicrobialsen_US
dc.subject.otherBacteriaen_US
dc.subject.otherS.A.U.C.E. projecten_US
dc.titleGeographical and ecological analysis of resistance, coresistance, and coupled resistance to antimicrobials in respiratory pathogenic bacteria in Spainen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1128/AAC.49.5.1965-1972.2005en_US
dc.identifier.scopus20944431706-
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dc.description.lastpage1972en_US
dc.description.firstpage1965en_US
dc.relation.volume49en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr4,379-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.fullNameMartín Sánchez, Antonio Manuel-
Colección:Artículos
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