Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/51270
Título: Geographical and ecological analysis of resistance, coresistance, and coupled resistance to antimicrobials in respiratory pathogenic bacteria in Spain
Autores/as: Pérez-Trallero, Emilio
García-De-La-Fuente, Celia
García-Rey, César
Baquero, Fernando
Aguilar, Lorenzo
Dal-Ré, Rafael
García-De-Lomas, Juan
Ausina, Vicente
Diosdado, Nieves
López-Hontangas, Jose L.
Barrón, Jorge
Vilar, Begoña
Marco, Francesc
Jiménez-De-Anta, María T.
Romero, Dolores
González-Rodríguez, Manuel
Casal, Manuel
Ibarra, Ana
Latorre, Cristina
Gené, Amadeo
De-La-Rosa, Manuel
Martínez-Brocal, Antonio
Calbo, Luis
Alados, Juan C.
Martín-Sánchez, Antonio M. 
Cañas, Fernando
Bouza, Emilio
Cercenado, Emilia
García-Perea, Adela
Lozano, Ana
Cantón, Rafael
Fenoll, Asunción
Pinedo, Alfonso
Sánchez-Bernal, María A.
Ruiz, Joaquín
Simarro, Encarnación
Alomar, Pedro
Pérez, Jose L.
García-Rodríguez, Jose A.
Trujillano, Ignacio
Marimón, Jose M.
Burgada, Antonia
García-Riestra, Carlos
García-Regueiro, Benito
Perea, Evelio
Nogueira, Jose M.
Gobernado, Miguel
Esteban, Encarnación
Lerma, Mercedes
Landínez, Ricardo
Tejero, Dolores
Torres, Julio
Vasallo, Francisco J.
Rubio, Carmen
Clasificación UNESCO: 32 Ciencias médicas
320103 Microbiología clínica
Palabras clave: Antimicrobials
Bacteria
S.A.U.C.E. project
Fecha de publicación: 2005
Publicación seriada: Antimicrobial Agents and Chemotherapy 
Resumen: A multicenter susceptibility surveillance (the S.A.U.C.E. project) including 2,721 Streptococcus pneumoniae, 3,174 Streptococcus pyogenes, and 2,645 Haemophilus influenzae consecutive isolates was carried out in 25 hospitals all over Spain from November 2001 to October 2002 to evaluate the current epidemiology of resistance of the main bacteria involved in community-acquired respiratory tract infections. Susceptibility testing was performed in a single centralized laboratory by a broth microdilution method. The prevalence of resistant S. pneumoniae strains was 0.4% for cefotaxime, 4.4% for amoxicillin and amoxicillin-clavulanic acid, 25.6% for cefuroxime-axetil, 34.5% for erythromycin, clarithromycin, and azithromycin, and 36.0% for cefaclor. Phenotypes of resistance to erythromycin were MLSB (macrolide-lincosamide-streptogramin B) in 89.9% (gene ermB) and M (macrolide) in 9.7% of cases (gene mefA). No strain harbored both genes simultaneously. Serotypes 19, 6, 23, 14, and 3 were the most prevalent, accounting for 54.6% of the total isolates. Resistance to macrolides seems to be the most alarming point, since among penicillin-susceptible isolates it reached 15.1% compared to 55.8% among penicillin-resistant strains. Geographically, a number of regions had rates of erythromycin resistance above 40% (even higher in children). Resistance to erythromycin was also high in S. pyogenes isolates: mean regional 33.2%, beta-lactamase-producing H. influenzae were 20%, whereas 4.4% had a beta-lactamase-negative, ampicillin-resistant phenotype. We highlight the importance of different geographical frequencies of coresistance (associations of resistance to different drugs within the same species) and coupled resistance (association of resistance between different species) probably resulting from different local coselective events.
URI: http://hdl.handle.net/10553/51270
ISSN: 0066-4804
DOI: 10.1128/AAC.49.5.1965-1972.2005
Fuente: Antimicrobial Agents and Chemotherapy[ISSN 0066-4804],v. 49, p. 1965-1972
Colección:Artículos
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