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Title: Hip Osteoarthritis in Dogs: A Randomized Study Using Mesenchymal Stem Cells from Adipose Tissue and Plasma Rich in Growth Factors
Authors: Cuervo, Belen
Rubio, Monica
Sopena, Joaquin
Dominguez, Juan Manuel
Vilar Guereño, José Manuel 
Morales Doreste, Manuel Francisco 
Cugat, Ramón
Carrillo, Jose Maria
UNESCO Clasification: 310907 Patología
Keywords: Adipose Derived Mesenchymal Stem Cells
Plasma Rich In Growth Factors
Issue Date: 2014
Journal: International Journal of Molecular Sciences 
Abstract: The aim of this study was to compare the efficacy and safety of a single intra-articular injection of adipose mesenchymal stem cells (aMSCs) versus plasma rich in growth factors (PRGF) as a treatment for reducing symptoms in dogs with hip osteoarthritis (OA). Methods: This was a randomized, multicenter, blinded, parallel group. Thirty-nine dogs with symptomatic hip OA were assigned to one of the two groups, to receive aMSCs or PRGF. The primary outcome measures were pain and function subscales, including radiologic assessment, functional limitation and joint mobility. The secondary outcome measures were owners' satisfaction questionnaire, rescue analgesic requirement and overall safety. Data was collected at baseline, then, 1, 3 and 6 months post-treatment. Results: OA degree did not vary within groups. Functional limitation, range of motion (ROM), owner's and veterinary investigator visual analogue scale (VAS), and patient's quality of life improved from the first month up to six months. The aMSCs group obtained better results at 6 months. There were no adverse effects during the study. Our findings show that aMSCs and PRGF are safe and effective in the functional analysis at 1, 3 and 6 months; provide a significant improvement, reducing dog's pain, and improving physical function. With respect to basal levels for every parameter in patients with hip OA, aMSCs showed better results at 6 months.
ISSN: 1661-6596
DOI: 10.3390/ijms150813437
Source: International Journal of Molecular Sciences [ISSN 1422-0067], v. 15 (8), p. 13437-13460, (Julio 2014)
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