Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/51201
Title: Clinical and immune aspects of idiopathic acute tubulointerstitial nephritis and uveitis syndrome
Authors: Rodriguez-Perez, Jose Carlos 
Cruz-Alamo, Manuel
Perez-Aciego, Paloma
Macia-Heras, Manuel
Naranjohernandez, A 
Plaza-Toledano, Celia
Hortal-Cascon, Luis
Fernandez-Rodriguez, Ana
UNESCO Clasification: 32 Ciencias médicas
320506 Nefrología
Keywords: Interstitial nephritis
Uveitis
T lymphocytes
Cellular immunity
Issue Date: 1995
Journal: American Journal of Nephrology 
Abstract: Five patients with idiopathic interstitial nephritis and uveitis without bone marrow granulomas were followed-up for 1 year. Ophthalmological examination revealed bilateral anterior uveitis. Light microscopy of the renal tissue revealed predominant lymphocyte infiltration of the interstitium. Immunohistochemical analysis revealed a clear predominance of memory T lymphocytes (CD45RO+) in the interstitial and tubular infiltration. HLA typing, and immunophenotypic studies of peripheral blood mononuclear cells including absolute lymphocyte and monocyte counts were assessed. The patients’ peripheral T-cell subpopulation did not significantly differ from control studies. With steroid treatment maintained during a period of 6-9 months renal function and uveitis responded dramatically in all patients. After 1-year follow-up, only 1 patient showed a relapse of uveitis, but there was complete clinical recovery of the nephritis in all 5 patients. The aim of this study was to describe the 1-year follow-up of 5 new cases of acute tubulointerstitial nephritis and uveitis syndrome, and assess some aspects of their cellular immunity.
URI: http://hdl.handle.net/10553/51201
ISSN: 0250-8095
DOI: 10.1159/000168871
Source: American Journal of Nephrology[ISSN 0250-8095],v. 15, p. 386-391
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

30
checked on Jun 26, 2022

WEB OF SCIENCETM
Citations

26
checked on Jun 26, 2022

Page view(s)

17
checked on Apr 2, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.