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http://hdl.handle.net/10553/51118
| Título: | Synthesis of new oxazolidine, oxazolidin‐2‐one and perhydro‐1,4‐oxazine derivatives of arylethanolamine as potential beta3‐adrenoceptor agonists | Autores/as: | Monge, Antonio Aldana, Ignacio Cerecetto, Hugo Rivero, Argimiro |
Clasificación UNESCO: | 2306 Química orgánica | Fecha de publicación: | 1995 | Editor/a: | 0022-152X | Publicación seriada: | Journal of Heterocyclic Chemistry | Resumen: | The synthesis of new cyclic compounds, arylethanolamine derivatives, with potential beta3‐adrenoceptor agonist selectivity, which are associated with thermogenesis and regulation of insulin release, are described. Oxazolidine, oxazolidin‐2‐one, and perhydro‐1,4‐oxazine derivatives were obtained. The preliminary evaluation of the pharmacological effects of some of the synthesized compounds showed an activation of lypolysis in rat adipocytes with potency and efficiency similar to that observed for other accredited beta3‐adrenergic agonists. | URI: | http://hdl.handle.net/10553/51118 | ISSN: | 0022-152X | DOI: | 10.1002/jhet.5570320504 | Fuente: | Journal of Heterocyclic Chemistry [ISSN 0022-152X], v. 32, p. 1429-1439 |
| Colección: | Artículos |
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