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Title: Clinicopathologic analysis of uterine sarcomas from a single institution in the Canary Islands
Authors: Benito, Virginia
Lubrano, Amina
Arencibia, Octavio
Andújar, Miguel 
Álvarez León, Eva Elisa 
Medina Ramos, Norberto Fidel 
Falcón, Juan Miguel
Falcón, Orlando
UNESCO Clasification: 32 Ciencias médicas
320108 Ginecología
320101 Oncología
Keywords: Adenosarcoma
Endometrial stromal sarcoma
Malignant mixed müllerian tumors
Uterine sarcoma
Issue Date: 2009
Journal: International Journal of Gynecology and Obstetrics 
Abstract: Objective To evaluate the clinicopathologic data and prognostic factors for patients with uterine sarcomas treated at a single institution, with special emphasis on malignant mixed müllerian tumors (MMMT). Methods Medical and anatomic pathology records were reviewed. Survival rates were analyzed using the Kaplan-Meier method. Results The study included 89 patients: 48.4% with MMMT; 22.4% with leiomyosarcomas; 20.2% with endometrial stromal sarcomas; and 9% with adenosarcomas. FIGO stages I, II, III, and IV were identified in 57.3%, 9.0%, 22.5%, and 7.8% of patients respectively. Event-free survival rates after 2, 5, and 10 years were 70%, 61%, and 55% respectively, with a median time of 90 months (95% CI, 41–140 months). Overall survival rates after 2, 5, and 10 years were 50%, 45%, and 39% respectively, with a median time of 43 months (95% CI, 3–83 months). Multivariate analysis showed that stage, histology, tumor size, and parity had an independent influence on overall survival. Conclusions MMMT are the most aggressive tumors and their behavior strongly resembles that of high-grade endometrial adenocarcinoma. Prognostic factors affecting survival were stage, histology, tumor size, and parity.
ISSN: 0020-7292
DOI: 10.1016/j.ijgo.2009.05.020
Source: International Journal of Gynecology and Obstetrics[ISSN 0020-7292],v. 107(1), p. 44-49 (Octubre 2009)
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