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http://hdl.handle.net/10553/51088
Title: | Clinicopathologic analysis of uterine sarcomas from a single institution in the Canary Islands | Authors: | Benito, Virginia Lubrano, Amina Arencibia, Octavio Andújar, Miguel Álvarez León, Eva Elisa Medina Ramos, Norberto Fidel Falcón, Juan Miguel Falcón, Orlando |
UNESCO Clasification: | 32 Ciencias médicas 320108 Ginecología 320101 Oncología |
Keywords: | Adenosarcoma Endometrial stromal sarcoma Malignant mixed müllerian tumors Leiomyosarcoma Uterine sarcoma |
Issue Date: | 2009 | Journal: | International Journal of Gynecology and Obstetrics | Abstract: | Objective To evaluate the clinicopathologic data and prognostic factors for patients with uterine sarcomas treated at a single institution, with special emphasis on malignant mixed müllerian tumors (MMMT). Methods Medical and anatomic pathology records were reviewed. Survival rates were analyzed using the Kaplan-Meier method. Results The study included 89 patients: 48.4% with MMMT; 22.4% with leiomyosarcomas; 20.2% with endometrial stromal sarcomas; and 9% with adenosarcomas. FIGO stages I, II, III, and IV were identified in 57.3%, 9.0%, 22.5%, and 7.8% of patients respectively. Event-free survival rates after 2, 5, and 10 years were 70%, 61%, and 55% respectively, with a median time of 90 months (95% CI, 41–140 months). Overall survival rates after 2, 5, and 10 years were 50%, 45%, and 39% respectively, with a median time of 43 months (95% CI, 3–83 months). Multivariate analysis showed that stage, histology, tumor size, and parity had an independent influence on overall survival. Conclusions MMMT are the most aggressive tumors and their behavior strongly resembles that of high-grade endometrial adenocarcinoma. Prognostic factors affecting survival were stage, histology, tumor size, and parity. | URI: | http://hdl.handle.net/10553/51088 | ISSN: | 0020-7292 | DOI: | 10.1016/j.ijgo.2009.05.020 | Source: | International Journal of Gynecology and Obstetrics[ISSN 0020-7292],v. 107(1), p. 44-49 (Octubre 2009) |
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