Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50963
Title: Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity
Authors: Thomsen, J. J.
Rentsch, R. L.
Robach, P.
Calbet, J. A. L. 
Boushel, R.
Rasmussen, P.
Juel, C.
Lundby, C.
UNESCO Clasification: 241106 Fisiología del ejercicio
Keywords: rHuEpo
Epo
Doping
Exercise
VO2max
Issue Date: 2007
Publisher: 1439-6319
Journal: European Journal of Applied Physiology 
Abstract: The effects of recombinant human erythropoietin (rHuEpo) treatment on aerobic power (VO2max) are well documented, but little is known about the effects of rHuEpo on submaximal exercise performance. The present study investigated the effect on performance (ergometer cycling, 20–30 min at 80% of maximal attainable workload), and for this purpose eight subjects received either 5,000 IU rHuEpo or placebo every second day for 14 days, and subsequently a single dose of 5,000 IU/placebo weekly/10 weeks. Exercise performance was evaluated before treatment and after 4 and 11 weeks of treatment. With rHuEpo treatment VO2max increased (P < 0.05) by 12.6 and 11.6% in week 4 and 11, respectively, and time-to-exhaustion (80% VO2max) was increased by 54.0 and 54.3% (P < 0.05) after 4 and 11 weeks of treatment, respectively. However, when normalizing the workload to the same relative intensity (only done at time point week 11), TTE was decreased by 26.8% as compared to pre rHuEpo administration. In conclusion, in healthy non-athlete subjects rHuEpo administration prolongs submaximal exercise performance by about 54% independently of the approximately 12% increase in VO2max.
URI: http://hdl.handle.net/10553/50963
ISSN: 1439-6319
DOI: 10.1007/s00421-007-0522-8
Source: European Journal Of Applied Physiology[ISSN 1439-6319],v. 101 (4), p. 481-486
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