Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50945
DC FieldValueLanguage
dc.contributor.authorHelge, Jørn W.en_US
dc.contributor.authorKlein, Ditte K.en_US
dc.contributor.authorAndersen, Thor Munchen_US
dc.contributor.authorvan Hall, Gerriten_US
dc.contributor.authorCalbet, Joseen_US
dc.contributor.authorBoushel, Roberten_US
dc.contributor.authorSaltin, Bengten_US
dc.contributor.otherHelge, Jorn-
dc.contributor.otherCalbet, Jose A-
dc.contributor.othervan Hall, Gerrit-
dc.date.accessioned2018-11-24T20:07:45Z-
dc.date.available2018-11-24T20:07:45Z-
dc.date.issued2011en_US
dc.identifier.issn0958-0670en_US
dc.identifier.urihttp://hdl.handle.net/10553/50945-
dc.description.abstractExercising muscle releases interleukin‐6 (IL‐6), but the mechanisms controlling this process are poorly understood. This study was performed to test the hypothesis that the IL‐6 release differs in arm and leg muscle during whole‐body exercise, owing to differences in muscle metabolism. Sixteen subjects (10 men and six women, with body mass index 24 ± 1 kg m−2 and peak oxygen uptake 3.4 ± 0.6 l min−1) performed a 90 min combined arm and leg cycle exercise at 60% of maximal oxygen uptake. The subjects arrived at the laboratory having fasted overnight, and catheters were placed in the femoral artery and vein and in the subclavian vein. During exercise, arterial and venous limb blood was sampled and arm and leg blood flow were measured by thermodilution. Lean limb mass was measured by dual‐energy X‐ray absorbtiometry scanning. Before and after exercise, biopsies were obtained from vastus lateralis and deltoideus. During exercise, IL‐6 release was similar between men and women and higher (P < 0.05) from arms than legs (1.01 ± 0.42 and 0.33 ± 0.12 ng min−1 (kg lean limb mass)−1, respectively). Blood flow (425 ± 36 and 554 ± 35 ml min−1 (kg lean limb mass)−1) and fatty acid uptake (26 ± 7 and 47 ± 7 μmol min−1 (kg lean limb mass)−1) were lower, glucose uptake similar (51 ± 12 and 41 ± 8 mmol min−1 (kg lean limb mass)−1) and lactate release higher (82 ± 32 and −2 ± 12 μmol min−1 (kg lean limb mass)−1) in arms than legs, respectively, during exercise (P < 0.05). No correlations were present between IL‐6 release and exogenous substrate uptakes. Muscle glycogen was similar in arms and legs before exercise (388 ± 22 and 428 ± 25 mmol (kg dry weight)−1), but after exercise it was only significantly lower in the leg (219 ± 29 mmol (kg dry weight)−1). The novel finding of a markedly higher IL‐6 release from the exercising arm compared with the leg during whole‐body exercise was not directly correlated to release or uptake of exogenous substrate, nor to muscle glycogen utilization.en_US
dc.languageengen_US
dc.publisher0958-0670-
dc.relation.ispartofExperimental Physiologyen_US
dc.sourceExperimental Physiology[ISSN 0958-0670],v. 96 (6), p. 590-598en_US
dc.subject241106 Fisiología del ejercicioen_US
dc.subject.otherHuman Skeletal-Muscle
dc.subject.otherSubstrate Utilization
dc.subject.otherGender Differences
dc.subject.otherGlycogen-Content
dc.subject.otherMenstrual-Cycle
dc.subject.otherFat Oxidation
dc.subject.otherHumans
dc.subject.otherMetabolism
dc.subject.otherIl-6
dc.subject.otherContraction
dc.titleInterleukin-6 release is higher across arm than leg muscles during whole-body exerciseen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1113/expphysiol.2010.056424
dc.identifier.scopus79956034308-
dc.identifier.isi000290629300005-
dcterms.isPartOfExperimental Physiology-
dcterms.sourceExperimental Physiology[ISSN 0958-0670],v. 96 (6), p. 590-598-
dc.contributor.authorscopusid20334409300-
dc.contributor.authorscopusid12761116500-
dc.contributor.authorscopusid53363200600-
dc.contributor.authorscopusid57191983922-
dc.contributor.authorscopusid7004323423-
dc.contributor.authorscopusid7003471688-
dc.contributor.authorscopusid7103099936-
dc.description.lastpage598-
dc.description.firstpage590-
dc.relation.volume96-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000290629300005-
dc.contributor.daisngid147585-
dc.contributor.daisngid3665847-
dc.contributor.daisngid11865041-
dc.contributor.daisngid209461-
dc.contributor.daisngid90295-
dc.contributor.daisngid220476-
dc.contributor.daisngid13919-
dc.identifier.investigatorRIDI-7096-2012-
dc.identifier.investigatorRIDH-6693-2015-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Helge, JW
dc.contributor.wosstandardWOS:Klein, DK
dc.contributor.wosstandardWOS:Andersen, TM
dc.contributor.wosstandardWOS:van Hall, G
dc.contributor.wosstandardWOS:Calbet, J
dc.contributor.wosstandardWOS:Boushel, R
dc.contributor.wosstandardWOS:Saltin, B
dc.date.coverdateEnero 2011
dc.identifier.ulpgces
dc.description.sjr1,241
dc.description.jcr3,211
dc.description.sjrqQ2
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameLópez Calbet, José Antonio-
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