Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50941
DC FieldValueLanguage
dc.contributor.authorRingholm, Stineen_US
dc.contributor.authorBienso, Rasmus S.en_US
dc.contributor.authorKiilerich, Kristianen_US
dc.contributor.authorGuadalupe-Grau, Ameliaen_US
dc.contributor.authorAachmann-Andersen, Niels Jacoben_US
dc.contributor.authorSaltin, Bengten_US
dc.contributor.authorPlomgaard, Peteren_US
dc.contributor.authorLundby, Carstenen_US
dc.contributor.authorWojtaszewski, Jorgen F.P.en_US
dc.contributor.authorCalbet, Jose A.en_US
dc.contributor.authorPilegaard, Henrietteen_US
dc.contributor.otherCalbet, Jose A-
dc.contributor.otherWojtaszewski, Jorgen-
dc.contributor.otherPilegaard, Henriette-
dc.contributor.otherGuadalupe-Grau, Amelia-
dc.contributor.otherwojtaszewski, jorgen-
dc.contributor.otherPlomgaard, Peter-
dc.date.accessioned2018-11-24T20:05:52Z-
dc.date.available2018-11-24T20:05:52Z-
dc.date.issued2011en_US
dc.identifier.issn0193-1849en_US
dc.identifier.urihttp://hdl.handle.net/10553/50941-
dc.description.abstractThe aim was to test the hypothesis that 7 days of bed rest reduces mitochondrial number and expression and activity of oxidative proteins in human skeletal muscle but that exercise-induced intracellular signaling as well as mRNA and microRNA (miR) responses are maintained after bed rest. Twelve young, healthy male subjects completed 7 days of bed rest with vastus lateralis muscle biopsies taken before and after bed rest. In addition, muscle biopsies were obtained from six of the subjects prior to, immediately after, and 3 h after 45 min of one-legged knee extensor exercise performed before and after bed rest. Maximal oxygen uptake decreased by 4%, and exercise endurance decreased nonsignificantly, by 11%, by bed rest. Bed rest reduced skeletal muscle mitochondrial DNA/nuclear DNA content 15%, hexokinase II and sirtuin 1 protein content 45%, 3-hydroxyacyl-CoA dehydrogenase and citrate synthase activity 8%, and miR-1 and miR-133a content 10%. However, cytochrome c and vascular endothelial growth factor (VEGF) protein content as well as capillarization did not change significantly with bed rest. Acute exercise increased AMP-activated protein kinase phosphorylation, peroxisome proliferator activated receptor- coactivator-1, and VEGF mRNA content in skeletal muscle before bed rest, but the responses were abolished after bed rest. The present findings indicate that only 7 days of physical inactivity reduces skeletal muscle metabolic capacity as well as abolishes exercise-induced adaptive gene responses, likely reflecting an interference with the ability of skeletal muscle to adapt to exercise.en_US
dc.languageengen_US
dc.publisher0193-1849-
dc.relation.ispartofAmerican Journal of Physiology - Endocrinology and Metabolismen_US
dc.sourceAmerican Journal Of Physiology-Endocrinology And Metabolism[ISSN 0193-1849],v. 301 (4), p. E649-E658en_US
dc.subject241106 Fisiología del ejercicioen_US
dc.subject.otherphysical inactivityen_US
dc.subject.otheroxidative capacityen_US
dc.subject.otherperoxisome proliferator-activated receptor- coactivator-1en_US
dc.subject.othercapillarizationen_US
dc.titleBed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscleen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1152/ajpendo.00230.2011
dc.identifier.scopus80053270813-
dc.identifier.isi000295576300009-
dcterms.isPartOfAmerican Journal Of Physiology-Endocrinology And Metabolism-
dcterms.sourceAmerican Journal Of Physiology-Endocrinology And Metabolism[ISSN 0193-1849],v. 301 (4), p. E649-E658-
dc.contributor.authorscopusid41662026800-
dc.contributor.authorscopusid36488930800-
dc.contributor.authorscopusid23467035900-
dc.contributor.authorscopusid25627673000-
dc.contributor.authorscopusid26632839600-
dc.contributor.authorscopusid7103099936-
dc.contributor.authorscopusid9432467400-
dc.contributor.authorscopusid57203056925-
dc.contributor.authorscopusid12774513500-
dc.contributor.authorscopusid7004323423-
dc.contributor.authorscopusid57204254611-
dc.description.lastpageE658-
dc.description.firstpageE649-
dc.relation.volume301-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000295576300009-
dc.contributor.daisngid2175766-
dc.contributor.daisngid1344881-
dc.contributor.daisngid2183831-
dc.contributor.daisngid861361-
dc.contributor.daisngid2081926-
dc.contributor.daisngid13919-
dc.contributor.daisngid345020-
dc.contributor.daisngid95120-
dc.contributor.daisngid78626-
dc.contributor.daisngid90295-
dc.contributor.daisngid93148-
dc.identifier.investigatorRIDH-6693-2015-
dc.identifier.investigatorRIDP-6583-2014-
dc.identifier.investigatorRIDM-2315-2014-
dc.identifier.investigatorRIDH-4961-2016-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Ringholm, S
dc.contributor.wosstandardWOS:Bienso, RS
dc.contributor.wosstandardWOS:Kiilerich, K
dc.contributor.wosstandardWOS:Guadalupe-Grau, A
dc.contributor.wosstandardWOS:Aachmann-Andersen, NJ
dc.contributor.wosstandardWOS:Saltin, B
dc.contributor.wosstandardWOS:Plomgaard, P
dc.contributor.wosstandardWOS:Lundby, C
dc.contributor.wosstandardWOS:Wojtaszewski, JFP
dc.contributor.wosstandardWOS:Calbet, JA
dc.contributor.wosstandardWOS:Pilegaard, H
dc.date.coverdateOctubre 2011
dc.identifier.ulpgces
dc.description.sjr2,539
dc.description.jcr4,746
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameLópez Calbet, José Antonio-
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