Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50745
Title: Inhaled steroids do not decrease bone mineral density but increase risk of fractures: Data from the GIUMO study group
Authors: Sosa, M. 
Saavedra, P.
Valero, C.
Guañabens, N.
Nogués, X.
del Pino-Montes, J.
Mosquera, J.
Alegre, J.
Gómez-Alonso, C.
Muñoz-Torres, M.
Quesada, M.
Pérez-Cano, R.
Jódar, E.
Torrijos, A.
Lozano-Tonkin, C.
Díaz-Curiel, M.
UNESCO Clasification: 32 Ciencias médicas
Keywords: Asthma
Bone Mineral Density
Fractures
Inhaled Steroids
Quantitative Ultrasonography, et al
Issue Date: 2006
Journal: Journal of Clinical Densitometry 
Abstract: Although the negative effect of systemic steroids on bone is well documented, there is not clear evidence about possible adverse effects of inhaled steroids on bone metabolism and fractures. A cross-sectional study was performed on 105 women suffering from bronchial asthma treated with inhaled steroids and 133 controls. Bone mineral density (BMD) was measured by quantitative ultrasonography (QUS) at the calcaneus and by dual X-ray absorptiometry (DXA), at both the lumbar spine and proximal femur. Patients suffering from bronchial asthma showed no statistically significant changes in BMD as measured by DXA or QUS, compared with controls. A higher prevalence of fractures was found in the group of women with bronchial asthma, with an age-adjusted odds ratio of 2.79 (95% CI: 1.19-6.54). Inhaled steroids do not appear to decrease BMD, but are associated with an increased risk of fracture in women.
URI: http://hdl.handle.net/10553/50745
ISSN: 1094-6950
DOI: 10.1016/j.jocd.2005.11.005
Source: Journal of Clinical Densitometry [ISSN 1094-6950], v. 9 (2), p. 154-158, (Abril-Junio 2006)
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