Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50737
Title: Bone mineral density and risk of fractures in aging, obese post-menopausal women with type 2 diabetes. The GIUMO study
Authors: Sosa, Manuel 
Saavedra, Pedro
Jódar, Esteban
Lozano-Tonkin, Carlos
Quesada, José Manuel
Torrijos, Antonio
Pérez-Cano, Ramón
Nogués, Xavier
Díaz-Curiel, Manuel
Moro, María Jesús
Gómez, Carlos
Mosquera, José
Alegre, Javier
Olmos, José
Muñoz-Torres, Manuel
Guañabens, Nuria
del Pino, Javier
Hawkins, Federico
Díaz-Guerra, G. Martinez
Cazorla, M. Serrano
Amétigo García, M. J.
Castiñeira, R. Cano
Cuenca, R.
Coya, J.
Hillman, N.
Gómez de Tejada, M. J.
Montoya, M. J.
Díez Pérez, A.
Sevillano Collantes, C.
Rodríguez, M.
Cannata, J. B.
Lago Castro, A.
Álvarez Lario, B.
Alonzo Valdivieso, J. L.
Díaz de la Madrid, C. Valero
González-Macías, J.
Alonzo, G.
Velasco, V.
Pedrero, R.
Hernández Hernández, D.
Sarmiento Santana, J.
Keywords: Hip Fracture
Older Women
Spanish Population
Body-Composition
Elderly-Women, et al
Issue Date: 2009
Publisher: 1594-0667
Journal: Aging - Clinical and Experimental Research 
Abstract: Background and aims: Type 2 diabetes mellitus (DM) has a high prevalence in aging obese postmenopausal women. It is not clear whether or not diabetes produces an increase in bone mineral density or an increase in fracture rates. Objective: The main objective of this study was to investigate whether type 2 DM produces a higher prevalence of vertebral, hip and non-vertebral fractures in obese post-menopausal Caucasian women. A secondary objective was to study the influence of DM in quantitative ultrasound measurements of the heel (QUS) and bone mineral density (BMD) measured by dual X-ray absorptiometry (DXA), in both lumbar spine (L2-L4) and proximal femur. Method: This study was a prospective cohort of 111 patients with type 2 DM and 91 control individuals (CTR) over age 65 and obese, recruited from 16 centers in Spain. Main Outcome Measures: Lateral dorsal and lumbar X-rays were performed to assess vertebral fractures. Hip and non-vertebral fractures were noted from medical records, written reports or X-ray studies. QUS measurements were made of the calcaneus and BMD measurements of the lumbar spine (L2-L4) and proximal femur. Results: Patients had higher BMD in the lumbar spine (L2-L4) than controls (0.979 g/cm2 vs 0.927g/cm2, p=0.035), but we found no statistically significant differences in the proximal femur. QUS measurements showed similar values in both groups: BUA (69.3 dB/Mhz vs 66.7 dB/Mhz, p=0.291), SOS (1537 m/sg vs 1532 m/sg, p=0.249) and QUI (87.5 vs 83.7, p=0.153). No statistically significant differences were found in any case. There was no association between vertebral, hip and non-vertebral fractures and DM. The crude odds, ratio, without adjusting was 1.045 (CI 95% 0.531; 2.059), and the adjusted odds ratio was 0.927 (CI 95% 0.461; 1.863). Conclusions: In obese post-menopausal Caucasian women, type 2 DM produces an increase in BMD of the lumbar spine without changes in BMD of the proximal femur or in QUS measurements of the heel. The prevalence of vertebral, hip and non-vertebral fractures did not increase in type 2 DM. © 2009, Editrice Kurtis.
URI: http://hdl.handle.net/10553/50737
ISSN: 1594-0667
DOI: 10.1007/BF03324895
Source: Aging Clinical and Experimental Research[ISSN 1594-0667],v. 21, p. 27-32
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