Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50730
Title: Vitamin D deficiency and high serum levels of vitamin A increase the risk of osteoporosis evaluated by Quantitative Ultrasound Measurements (QUS) in postmenopausal Spanish women
Authors: Mata-Granados, J. M.
Cuenca-Acevedo, R.
Luque de Castro, M. D.
Sosa, M. 
Quesada-Gómez, J. M.
Keywords: Bone-Mineral Density
Hypervitaminosis-A
D Insufficiency
Retinol Levels
Hip-Fractures, et al
Issue Date: 2010
Publisher: 0009-9120
Journal: Clinical biochemistry 
Abstract: Objectives: Association between vitamin D deficiency and excess of vitamin A as a potential risk factor of osteoporosis and fracture has been evaluated.Design and methods: 232 healthy postmenopausal women were studied. Serum parameters were analyzed by standard methods and fat-soluble vitamins by an own HPLC method. QUS measurement of the calcaneal bone was carried out by Sahara.Results: 124 patients were considered non-osteoporotic and 101 (44.9%) were osteoporotic. The prevalence of high serum levels of retinol was 36.4% and vitamin D deficiency was 70.1%. 60.4% of women with vitamin D deficiency have high serum levels of retinol.In the whole population, the increased risk of osteoporosis was up to three times higher for the highest retinol quintile, as compared with the lowest retinol quintile. Whereas in women with vitamin D deficiency the risk of osteoporosis increased was up 5 times higher than women in the lowest quintile of retinol.Conclusions: Our results show that high retinol levels together with vitamin D deficiency are hitherto an overlooked risk factor for osteoporosis. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/10553/50730
ISSN: 0009-9120
DOI: 10.1016/j.clinbiochem.2010.06.001
Source: Clinical Biochemistry[ISSN 0009-9120],v. 43, p. 1064-1068
Appears in Collections:Artículos
Show full item record

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.