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Title: Prevalence of vertebral fracture in postmenopausal women with lumbar osteopenia using MorphoXpress® (OSTEOXPRESS Study)
Authors: Arboleya, Luis
Díaz-Curiel, Manuel
Del Río, Luis
Blanch, Josep
Díez-Pérez, Adolfo
Guañabens, Nuria
Quesada, José Manuel
Sosa, Manuel 
Gómez, Carlos
Muñoz-Torres, Manuel
Ramírez, Esther
Combalia, Josep
UNESCO Clasification: 32 Ciencias médicas
Issue Date: 2010
Journal: Aging - Clinical and Experimental Research 
Abstract: Vertebral fracture (VF) is the most common complication of osteoporosis. However, more than half of all VF are asymptomatic and may go unnoticed, even in patients with osteoporosis. Our aim was to assess the prevalence of VF in postmenopausal women with osteopenic lumbar densitometry by means of vertebral morphometry, using the MorphoXpress® software. This was an epidemiological, cross-sectional, multicenter study conducted among 289 postmenopausal women (>1 year of amenorrhoea), diagnosed with lumbar osteopenia (not due to chronic treatment with corticosteroids or immobilization). Vertebral deformities ≥20% were considered as VF. Demographic and clinical characteristics showed mean age (±SD) 64±9 years, body mass index 27±5 kg/m2, and time from diagnosis of 2±3 years. A total of 25% of subjects had a family history of osteoporotic fracture in first-degree relatives, and 23% had previous fragility fracture. The prevalence of VF was 50% (CI 95% 44-56), the most frequent being the dorsal wedge (34%). Previous fragility fracture was a risk factor for VF (OR 3.13, p=0.0004). A total of 76.5% of patients were receiving treatment, mainly calcium and vitamin D supplements (70%) and bisphosphonates (27%). MorphoXpress® revealed that 50% of postmenopausal women with osteopenic lumbar densitometry showed VF. This result is important since only 7% of all evaluated subjects had previously been diagnosed with VF.
ISSN: 1594-0667
DOI: 10.3275/6799
Source: Aging Clinical and Experimental Research[ISSN 1594-0667],v. 22(5-6), p. 419-426 (Octubre 2010)
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