Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/50697
Título: Centroblastic transformation of chronic lymphocytic leukaemia with primary skin involvement—cutaneous presentation of Richter's syndrome
Autores/as: ZARCO, C.
LAHUERTA‐PALACIOS, J. J.
BORREGO, L. 
TOSCANO, R.
GIL, R.
IGLESIAS, L.
Clasificación UNESCO: 32 Ciencias médicas
320106 Dermatología
Palabras clave: Lymphocytic leukaemia
Richter's syndrome
Fecha de publicación: 1993
Publicación seriada: Clinical and Experimental Dermatology 
Resumen: The development of a large-cell non-Hodgkin's lymphoma in a patient suffering from chronic lymphocytic leukaemia is known as Richter's syndrome, representing one of the possible anaplastic transformations of the leukaemia. Cutaneous involvement is an extremely rare event. The case of a 45-year-old man with B-cell chronic lymphocytic leukaemia is reported. Five years later multiple cutaneous nodules developed on his extremities. Biopsies of the skin showed a diffuse large-cell lymphoma, bearing the same cell surface immunoglobulin light chain isotype as the leukaemia, suggesting the original relationship between both neoplasms.
URI: http://hdl.handle.net/10553/50697
ISSN: 0307-6938
DOI: 10.1111/j.1365-2230.1993.tb02184.x
Fuente: Clinical and Experimental Dermatology[ISSN 0307-6938],v. 18(3), p. 263-267 (Mayo 1993)
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