|Title:||Centroblastic transformation of chronic lymphocytic leukaemia with primary skin involvement—cutaneous presentation of Richter's syndrome||Authors:||ZARCO, C.
LAHUERTA‐PALACIOS, J. J.
|UNESCO Clasification:||32 Ciencias médicas
|Issue Date:||1993||Journal:||Clinical and Experimental Dermatology||Abstract:||The development of a large-cell non-Hodgkin's lymphoma in a patient suffering from chronic lymphocytic leukaemia is known as Richter's syndrome, representing one of the possible anaplastic transformations of the leukaemia. Cutaneous involvement is an extremely rare event. The case of a 45-year-old man with B-cell chronic lymphocytic leukaemia is reported. Five years later multiple cutaneous nodules developed on his extremities. Biopsies of the skin showed a diffuse large-cell lymphoma, bearing the same cell surface immunoglobulin light chain isotype as the leukaemia, suggesting the original relationship between both neoplasms.||URI:||http://hdl.handle.net/10553/50697||ISSN:||0307-6938||DOI:||10.1111/j.1365-2230.1993.tb02184.x||Source:||Clinical and Experimental Dermatology[ISSN 0307-6938],v. 18(3), p. 263-267 (Mayo 1993)|
|Appears in Collections:||Artículos|
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