Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50697
Title: Centroblastic transformation of chronic lymphocytic leukaemia with primary skin involvement—cutaneous presentation of Richter's syndrome
Authors: ZARCO, C.
LAHUERTA‐PALACIOS, J. J.
BORREGO, L. 
TOSCANO, R.
GIL, R.
IGLESIAS, L.
UNESCO Clasification: 32 Ciencias médicas
320106 Dermatología
Keywords: Lymphocytic leukaemia
Richter's syndrome
Issue Date: 1993
Journal: Clinical and Experimental Dermatology 
Abstract: The development of a large-cell non-Hodgkin's lymphoma in a patient suffering from chronic lymphocytic leukaemia is known as Richter's syndrome, representing one of the possible anaplastic transformations of the leukaemia. Cutaneous involvement is an extremely rare event. The case of a 45-year-old man with B-cell chronic lymphocytic leukaemia is reported. Five years later multiple cutaneous nodules developed on his extremities. Biopsies of the skin showed a diffuse large-cell lymphoma, bearing the same cell surface immunoglobulin light chain isotype as the leukaemia, suggesting the original relationship between both neoplasms.
URI: http://hdl.handle.net/10553/50697
ISSN: 0307-6938
DOI: 10.1111/j.1365-2230.1993.tb02184.x
Source: Clinical and Experimental Dermatology[ISSN 0307-6938],v. 18(3), p. 263-267 (Mayo 1993)
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