Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50667
Title: Office-based radiation therapy for cutaneous carcinoma: Evaluation of 710 treatments
Authors: Hernández-Machin, Buenaventura
Borrego, Leopoldo 
Gil-garcía, Miguel
Hernández, Buenaventura H.
Keywords: Basal-Cell Carcinoma
Skin-Cancer
Ionizing-Radiation
Recurrence Rates
Radiotherapy, et al
Issue Date: 2007
Publisher: 0011-9059
Journal: International journal of dermatology 
Abstract: Skin cancers are the most common malignancies and, historically, ionizing radiation has played an important role in their treatment. However, less experienced dermatologists generally consider radiation last in the line of therapeutic options. The authors sought to evaluate the effectiveness and safety of office-based elective radiation therapy for cutaneous carcinoma.A retrospective study of 604 basal cell carcinomas (BCCs) and 106 squamous cell carcinomas (SCCs) irradiated between 1971-96 was performed. The percentage of patients who developed tumor recurrence during the follow-up period was calculated using Kaplan-Meier survival curves. Cox's proportional model was used to assess the prognostic factors that might have influenced the recurrences.The recurrence rates for BCC and SCC were 11.5 and 16.5 per 1000 patient-years, respectively. The 5-year cure rates were 94.4% for BCC and 92.7% for SCC, and the 15-year cure rates were 84.8% and 78.6%, respectively. Tumor location on the nasolabial fold (OR 4.4; 95% IC, 1.3-14.7) and tumor size >= 10 mm (OR 2.14; 95% IC, 1.03-4.45) were independent predictors of BCC recurrence. This study suggested that radiation therapy is an effective treatment for BCC and SCC and should be considered as a first option in many cases.
URI: http://hdl.handle.net/10553/50667
ISSN: 0011-9059
DOI: 10.1111/j.1365-4632.2006.03108.x
Source: International Journal of Dermatology[ISSN 0011-9059],v. 46, p. 453-459
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