Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/50613
Título: Insulin resistance explains the relationship between novel cardiovascular risk factors and hypertension. The Telde Study
Autores/as: Wägner, A. M. 
Wiebe, J. C.
Boronat, M. 
Saavedra Santana, Pedro 
Marrero, D.
Varillas, F.
Nóvoa, F. J.
Clasificación UNESCO: 320502 Endocrinología
Palabras clave: HOMA
PAI-1
Metabolic Syndrome
Obesity
Triglyceride
Fecha de publicación: 2011
Publicación seriada: Journal of endocrinological investigation 
Resumen: Background: Most studies describing an association between hypertension and an inflammatory/pro-thrombotic state do not assess insulin resistance. Aim: To examine the association between hypertension and new cardiovascular risk factors when considering both classical risk factors and insulin resistance. Methods: In a population-based sample of 10:30 subjects, clinical information and blood samples were obtained. Subjects were classified according to the presence or absence of hypertension, and insulin resistance was estimated using the homeostasis model of assessment (HOMA). To identify variables independently associated with hypertension, a four-model multiple logistic regression was performed: model 1 included novel risk factors (Plasminogen Activator Inhibitor-1 [PAI-1], fibrinogen, von Willebrand Factor [vWF], lipoprotein(a), homocysteine and C-reactive Protein [CRP]); model 2, novel risk factors plus HOMA; model 3 included both classical (smoking, triglycerides, HDL cholesterol, total cholesterol, waist circumference and diabetes) and novel risk factors and model 4, model 3 plus HOMA. All were adjusted for age, BMI and gender and compared using Akaike's Information Criterion (AIC). Results: In model 1, only PAI-1, age and BMI showed association with hypertension. When HOMA and classical risk factors were also included, PAI-1 was replaced by triglyceride, smoking and diabetes. The lowest AIC value (best adjustment) was displayed by model 4, comprising all of the variables. Only age, BMI, HOMA and smoking remained significantly associated with hypertension. Conclusions: The novel cardiovascular risk factors assessed do not add information as markers of hypertension when classical risk factors or insulin resistance are included in the evaluation.
URI: http://hdl.handle.net/10553/50613
ISSN: 0391-4097
DOI: 10.3275/7325
Fuente: Journal of endocrinological investigation [ISSN 0391-4097], v. 34 (11), p. e409-e412, (Diciembre 2011)
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