1. accedaCRIS
  2. Publicaciones
  3. Artículos
Please use this identifier to cite or link to this item: https://accedacris.ulpgc.es/handle/10553/50578
DC FieldValueLanguage
dc.contributor.authorGonzález, Antonio G.en_US
dc.contributor.authorHernández, Juan C.en_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorPadrón, Juan I.en_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.authorQuintana, Jen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherQuintana, Jose-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherPadron, Juan-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-24T17:08:34Z-
dc.date.available2018-11-24T17:08:34Z-
dc.date.issued2003en_US
dc.identifier.issn0163-3864en_US
dc.identifier.urihttps://accedacris.ulpgc.es/handle/10553/50578-
dc.description.abstractFrom the stem bark of Dracaena draco, three new compounds, namely, draconins A-C (1-3), were isolated, along with 17 known compounds. The structures of the new compounds isolated were elucidated on the basis of spectroscopic data interpretation. Several of the isolated compounds showed potent cytotoxic activities measured on the human leukemia cell line HL-60 (IC50's from 2.0 to 9.7 muM at 72 h). The mechanism by which compounds 1 and 2 display their cytostatic properties is through induction of cell death by apoptosis, as evaluated by fluorescence microscopy and DNA fragmentation.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Natural Productsen_US
dc.sourceJournal of Natural Products[ISSN 0163-3864],v. 66(6), p. 793-798 (Mayo 2023)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3209 Farmacologíaen_US
dc.subject.otherDragons Blooden_US
dc.subject.otherHl-60 Cellsen_US
dc.subject.otherLeukemiaen_US
dc.subject.otherGrowthen_US
dc.subject.otherAssayen_US
dc.titleSteroidal saponins from the bark of Dracaena draco and their cytotoxic activitiesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/np020517jen_US
dc.identifier.scopus0037528859-
dc.identifier.isi000183814600012-
dcterms.isPartOfJournal Of Natural Products-
dcterms.sourceJournal Of Natural Products[ISSN 0163-3864],v. 66 (6), p. 793-798-
dc.contributor.authorscopusid56387707800-
dc.contributor.authorscopusid55205608000-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid7003856519-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage798en_US
dc.description.firstpage793en_US
dc.relation.volume66en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000183814600012-
dc.contributor.daisngid914093-
dc.contributor.daisngid914093-
dc.contributor.daisngid5955669-
dc.contributor.daisngid5955669-
dc.contributor.daisngid136703-
dc.contributor.daisngid618078-
dc.contributor.daisngid384944-
dc.contributor.daisngid128315-
dc.contributor.daisngid5695465-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDI-7660-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages6en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Gonzalez, AG-
dc.contributor.wosstandardWOS:Hernandez, JC-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Padron, JI-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateMayo 2003en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,849-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameQuintana Aguiar, José Martín-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

57
checked on Jun 8, 2025

WEB OF SCIENCETM
Citations

52
checked on Jun 8, 2025

Page view(s)

104
checked on Jan 18, 2025

Google ScholarTM

Check

Altmetric


Share


Export metadata


Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.