Novel cytostatic lanostanoid triterpenes from Ganoderma australe

Abstract

Two new compounds 1 and 2, together with the known sterols ergosterol, 5,6-dehydroergosterol, and ergosterol peroxide, and four polyoxygenated lanostanoid triterpenes named applanoxidic acid A (3), C (4), F (5), and G (6) were isolated from the fungus Ganoderma australe. The structures of the new compounds were elucidated by means of spectroscopic techniques, while the known triterpenoids 3-6 were identified by comparing their spectral data with those reported in the literature. Compounds 1-6 inhibited the viability and growth of the HL-60 cell line.