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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50573
DC FieldValueLanguage
dc.contributor.authorHernández, Juan C.en_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorQuintana, Jen_US
dc.contributor.authorEstevez, Fen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-24T17:06:10Z-
dc.date.available2018-11-24T17:06:10Z-
dc.date.issued2004en_US
dc.identifier.issn0968-0896en_US
dc.identifier.urihttp://hdl.handle.net/10553/50573-
dc.description.abstractThis paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 +/- 0.9 muM at 72 h, with growth inhibition caused by the induction of apoptosis, as deter-mined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.en_US
dc.languageengen_US
dc.relation.ispartofBioorganic and Medicinal Chemistryen_US
dc.sourceBioorganic & Medicinal Chemistry[ISSN 0968-0896],v. 12 (16), p. 4423-4429en_US
dc.subject32 Ciencias médicasen_US
dc.subject3209 Farmacologíaen_US
dc.subject.otherPoly(Adp-Ribose) Polymeraseen_US
dc.subject.otherDragons Blooden_US
dc.subject.otherHl-60 Cellsen_US
dc.subject.otherApoptosisen_US
dc.subject.otherDiosgenylen_US
dc.subject.otherCleavageen_US
dc.subject.otherFlavansen_US
dc.titleIcogenin, a new cytotoxic steroidal saponin isolated from Dracaena dracoen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bmc.2004.06.009en_US
dc.identifier.scopus3242791746-
dc.identifier.isi000223181300010-
dcterms.isPartOfBioorganic & Medicinal Chemistry-
dcterms.sourceBioorganic & Medicinal Chemistry[ISSN 0968-0896],v. 12 (16), p. 4423-4429-
dc.contributor.authorscopusid55205608000-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage4429en_US
dc.description.firstpage4423en_US
dc.relation.volume12en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000223181300010-
dc.contributor.daisngid5955669-
dc.contributor.daisngid136703-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.contributor.daisngid114640-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages7en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Hernandez, JC-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateAgosto 2004en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,018-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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