Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/50573
| Title: | Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco | Authors: | Hernández, Juan C. León, Francisco Quintana, J Estevez, F Bermejo, Jaime |
UNESCO Clasification: | 32 Ciencias médicas 3209 Farmacología |
Keywords: | Poly(Adp-Ribose) Polymerase Dragons Blood Hl-60 Cells Apoptosis Diosgenyl, et al |
Issue Date: | 2004 | Journal: | Bioorganic and Medicinal Chemistry | Abstract: | This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 +/- 0.9 muM at 72 h, with growth inhibition caused by the induction of apoptosis, as deter-mined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1. | URI: | http://hdl.handle.net/10553/50573 | ISSN: | 0968-0896 | DOI: | 10.1016/j.bmc.2004.06.009 | Source: | Bioorganic & Medicinal Chemistry[ISSN 0968-0896],v. 12 (16), p. 4423-4429 |
| Appears in Collections: | Artículos |
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.