Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/50573
| Title: | Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco | Authors: | Hernández, Juan C. León, Francisco Quintana, J Estevez, F Bermejo, Jaime |
Keywords: | Poly(Adp-Ribose) Polymerase Dragons Blood Hl-60 Cells Apoptosis Diosgenyl, et al |
Issue Date: | 2004 | Publisher: | 0968-0896 | Journal: | Bioorganic and Medicinal Chemistry | Abstract: | This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 +/- 0.9 muM at 72 h, with growth inhibition caused by the induction of apoptosis, as deter-mined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1. (C) 2004 Elsevier Ltd. All rights reserved. | URI: | http://hdl.handle.net/10553/50573 | ISSN: | 0968-0896 | DOI: | 10.1016/j.bmc.2004.06.009 | Source: | Bioorganic & Medicinal Chemistry[ISSN 0968-0896],v. 12 (16), p. 4423-4429 |
| Appears in Collections: | Artículos |
SCOPUSTM
Citations
36
checked on Jul 25, 2021
WEB OF SCIENCETM
Citations
31
checked on Jul 25, 2021
Page view(s)
17
checked on Jul 24, 2021
Google ScholarTM
Check
Altmetric
Share
Export metadata
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.