Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50573
Title: Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco
Authors: Hernández, Juan C.
León, Francisco
Quintana, J 
Estevez, F 
Bermejo, Jaime
UNESCO Clasification: 32 Ciencias médicas
3209 Farmacología
Keywords: Poly(Adp-Ribose) Polymerase
Dragons Blood
Hl-60 Cells
Apoptosis
Diosgenyl, et al
Issue Date: 2004
Journal: Bioorganic and Medicinal Chemistry 
Abstract: This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 +/- 0.9 muM at 72 h, with growth inhibition caused by the induction of apoptosis, as deter-mined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.
URI: http://hdl.handle.net/10553/50573
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2004.06.009
Source: Bioorganic & Medicinal Chemistry[ISSN 0968-0896],v. 12 (16), p. 4423-4429
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