Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50569
DC FieldValueLanguage
dc.contributor.authorRomagnoli, Romeoen_US
dc.contributor.authorBaraldi, Pier Giovannien_US
dc.contributor.authorTabrizi, Mojgan Aghazadehen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.authorBorgatti, Monicaen_US
dc.contributor.authorGambari, Robertoen_US
dc.contributor.otherGambari, Roberto-
dc.contributor.otherBaraldi, Pier Giovanni-
dc.contributor.otherRomagnoli, Romeo-
dc.contributor.otherAghazadeh Tabrizi, Mojgan-
dc.contributor.otherBorgatti, Monica-
dc.contributor.otherEstevez, Francisco-
dc.date.accessioned2018-11-24T17:04:18Z-
dc.date.available2018-11-24T17:04:18Z-
dc.date.issued2005en_US
dc.identifier.issn0022-2623en_US
dc.identifier.urihttp://hdl.handle.net/10553/50569-
dc.description.abstractThe synthesis and biological activity of hybrids 8-18 prepared combining alpha-methylene-gamma-butyrolactones and alpha-bromoacryloylamides have been described and their structure -activity relationships discussed. All these heterobifunctional compounds demonstrate good antileukemic activity, significantly superior to that of both alkylating units alone. Using the human leukemia HL-60 cell line, selected compounds 10, 11, 13, and 17 were found to induce morphological changes and internucleosomal DNA fragmentation characteristic of apoptotic cell death.en_US
dc.languageengen_US
dc.relationNuevos Compuestos Antileucémicosen_US
dc.relation.ispartofJournal of Medicinal Chemistryen_US
dc.sourceJournal of Medicinal Chemistry [ISSN 0022-2623], v. 48 (24), p. 7906-7910 (Diciembre 2005)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3209 Farmacologíaen_US
dc.subject2390 Química farmacéuticaen_US
dc.subject.otherBenzoheterocyclic Derivativesen_US
dc.subject.otherAntitumor Agentsen_US
dc.subject.otherDistamycinen_US
dc.subject.otherCellsen_US
dc.subject.otherInhibitorsen_US
dc.subject.otherApoptosisen_US
dc.subject.otherLeukemiaen_US
dc.subject.otherSpongesen_US
dc.subject.otherBindingen_US
dc.titleDesign, synthesis, and biological evaluation of hybrid molecules containing α-methylene-γ-butyrolactones and α-bromoacryloyl moietiesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/jm058012oen_US
dc.identifier.scopus28144433307-
dc.identifier.isi000233654900037-
dcterms.isPartOfJournal Of Medicinal Chemistry-
dcterms.sourceJournal Of Medicinal Chemistry[ISSN 0022-2623],v. 48 (24), p. 7906-7910-
dc.contributor.authorscopusid7101729609-
dc.contributor.authorscopusid7101681318-
dc.contributor.authorscopusid35458610100-
dc.contributor.authorscopusid7101636723-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7003682206-
dc.contributor.authorscopusid7102534350-
dc.description.lastpage7910en_US
dc.identifier.issue24-
dc.description.firstpage7906en_US
dc.relation.volume48en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000233654900037-
dc.contributor.daisngid32727-
dc.contributor.daisngid38403-
dc.contributor.daisngid240947-
dc.contributor.daisngid5695465-
dc.contributor.daisngid384944-
dc.contributor.daisngid90531-
dc.contributor.daisngid11355-
dc.identifier.investigatorRIDF-9555-2015-
dc.identifier.investigatorRIDB-7933-2017-
dc.identifier.investigatorRIDG-9887-2015-
dc.identifier.investigatorRIDI-9169-2014-
dc.identifier.investigatorRIDG-2611-2015-
dc.identifier.investigatorRIDK-5125-2014-
dc.description.numberofpages5en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Romagnoli, R-
dc.contributor.wosstandardWOS:Baraldi, PG-
dc.contributor.wosstandardWOS:Tabrizi, MA-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Borgatti, M-
dc.contributor.wosstandardWOS:Gambari, R-
dc.date.coverdateDiciembre 2005en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr4,926
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
crisitem.author.deptGIR IUIBS: Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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