Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/50569
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Romagnoli, Romeo | en_US |
dc.contributor.author | Baraldi, Pier Giovanni | en_US |
dc.contributor.author | Tabrizi, Mojgan Aghazadeh | en_US |
dc.contributor.author | Bermejo, Jaime | en_US |
dc.contributor.author | Estévez, Francisco | en_US |
dc.contributor.author | Borgatti, Monica | en_US |
dc.contributor.author | Gambari, Roberto | en_US |
dc.contributor.other | Gambari, Roberto | - |
dc.contributor.other | Baraldi, Pier Giovanni | - |
dc.contributor.other | Romagnoli, Romeo | - |
dc.contributor.other | Aghazadeh Tabrizi, Mojgan | - |
dc.contributor.other | Borgatti, Monica | - |
dc.contributor.other | Estevez, Francisco | - |
dc.date.accessioned | 2018-11-24T17:04:18Z | - |
dc.date.available | 2018-11-24T17:04:18Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.issn | 0022-2623 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/50569 | - |
dc.description.abstract | The synthesis and biological activity of hybrids 8-18 prepared combining alpha-methylene-gamma-butyrolactones and alpha-bromoacryloylamides have been described and their structure -activity relationships discussed. All these heterobifunctional compounds demonstrate good antileukemic activity, significantly superior to that of both alkylating units alone. Using the human leukemia HL-60 cell line, selected compounds 10, 11, 13, and 17 were found to induce morphological changes and internucleosomal DNA fragmentation characteristic of apoptotic cell death. | en_US |
dc.language | eng | en_US |
dc.relation | Nuevos Compuestos Antileucémicos | en_US |
dc.relation.ispartof | Journal of Medicinal Chemistry | en_US |
dc.source | Journal of Medicinal Chemistry [ISSN 0022-2623], v. 48 (24), p. 7906-7910 (Diciembre 2005) | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 3209 Farmacología | en_US |
dc.subject | 2390 Química farmacéutica | en_US |
dc.subject.other | Benzoheterocyclic Derivatives | en_US |
dc.subject.other | Antitumor Agents | en_US |
dc.subject.other | Distamycin | en_US |
dc.subject.other | Cells | en_US |
dc.subject.other | Inhibitors | en_US |
dc.subject.other | Apoptosis | en_US |
dc.subject.other | Leukemia | en_US |
dc.subject.other | Sponges | en_US |
dc.subject.other | Binding | en_US |
dc.title | Design, synthesis, and biological evaluation of hybrid molecules containing α-methylene-γ-butyrolactones and α-bromoacryloyl moieties | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1021/jm058012o | en_US |
dc.identifier.scopus | 28144433307 | - |
dc.identifier.isi | 000233654900037 | - |
dcterms.isPartOf | Journal Of Medicinal Chemistry | - |
dcterms.source | Journal Of Medicinal Chemistry[ISSN 0022-2623],v. 48 (24), p. 7906-7910 | - |
dc.contributor.authorscopusid | 7101729609 | - |
dc.contributor.authorscopusid | 7101681318 | - |
dc.contributor.authorscopusid | 35458610100 | - |
dc.contributor.authorscopusid | 7101636723 | - |
dc.contributor.authorscopusid | 7003810011 | - |
dc.contributor.authorscopusid | 7003682206 | - |
dc.contributor.authorscopusid | 7102534350 | - |
dc.description.lastpage | 7910 | en_US |
dc.identifier.issue | 24 | - |
dc.description.firstpage | 7906 | en_US |
dc.relation.volume | 48 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000233654900037 | - |
dc.contributor.daisngid | 32727 | - |
dc.contributor.daisngid | 38403 | - |
dc.contributor.daisngid | 240947 | - |
dc.contributor.daisngid | 5695465 | - |
dc.contributor.daisngid | 384944 | - |
dc.contributor.daisngid | 90531 | - |
dc.contributor.daisngid | 11355 | - |
dc.identifier.investigatorRID | F-9555-2015 | - |
dc.identifier.investigatorRID | B-7933-2017 | - |
dc.identifier.investigatorRID | G-9887-2015 | - |
dc.identifier.investigatorRID | I-9169-2014 | - |
dc.identifier.investigatorRID | G-2611-2015 | - |
dc.identifier.investigatorRID | K-5125-2014 | - |
dc.description.numberofpages | 5 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Romagnoli, R | - |
dc.contributor.wosstandard | WOS:Baraldi, PG | - |
dc.contributor.wosstandard | WOS:Tabrizi, MA | - |
dc.contributor.wosstandard | WOS:Bermejo, J | - |
dc.contributor.wosstandard | WOS:Estevez, F | - |
dc.contributor.wosstandard | WOS:Borgatti, M | - |
dc.contributor.wosstandard | WOS:Gambari, R | - |
dc.date.coverdate | Diciembre 2005 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.jcr | 4,926 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.project.principalinvestigator | Estévez Rosas, Francisco Jesús | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.orcid | 0000-0002-9728-2774 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Estévez Rosas, Francisco Jesús | - |
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