Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50554
Title: Secondary metabolites from two species of pulicaria and their cytotoxic activity
Authors: Triana, Jorge
Lõpez, Mariana
Pérez, Francisco Javier 
Leõn, Francisco
Quintana, Jose 
Estevez, Francisco 
Hernández, Juan C.
González-Platas, Javier
Brouard, Ignacio
Bermejo, Jaime
Keywords: Flavonoids
Triterpenoids
Constituents
Derivatives
Gonospermum
Issue Date: 2011
Publisher: 1612-1872
Journal: Chemistry and Biodiversity 
Abstract: Two new compounds, the sesquiterpene (1E,5E)-8 beta-acetoxy-4a-hydroxy-7 beta H-germacra-1(10),5-dien-14-oic acid (2), and a nor-sesquiterpene, (5E)-8 beta-acetoxy-4a-hydroxy-7 beta H-germacr-5-en-10-one (3), were isolated from Pulicaria canariensis ssp. lanata, along with ten known compounds, including the flavonoid 5,3'-dihydroxy-3,7,4'-trimethoxyflavone (4). From Pulicaria burchardii, we isolated seven known compounds; the physical and spectroscopic data of the triterpenoid 3 beta-hydroxytaraxaster-20-en-30-al (1) are reported. The structures of compounds 13 were determined on the basis of HR-MS, and 1D- and 2D-NMR studies. The structure of 2 was corroborated by X-ray crystal diffraction. Cell viability experiments revealed that the semisynthetic flavonoid 4b was the most cytotoxic compound against human leukemia cells, and the cytotoxicity was caused by induction of apoptosis, as determined by microscopy of nuclear changes.
URI: http://hdl.handle.net/10553/50554
ISSN: 1612-1872
DOI: 10.1002/cbdv.201000324
Source: Chemistry & Biodiversity[ISSN 1612-1872],v. 8 (11), p. 2080-2089
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