Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50553
Title: New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides
Authors: Pérez-Labrada, Karell
Brouard, Ignacio
Estévez, Sara 
Marrero, María Teresa
Estevez, Francisco 
Bermejo, Jaime
Rivera, Daniel G.
Keywords: Solanum Steroidal Glycosides
Diosgenyl Saponins
Hemolytic-Activity
Triterpenoid Saponins
Dioscin Derivatives, et al
Issue Date: 2012
Publisher: 0968-0896
Project: Evaluación de Potenciales Compuestos Antileucémicos. 
Journal: Bioorganic and Medicinal Chemistry 
Abstract: A variety of spirostan saponins and related glycosides were synthesized and evaluated for their cytotoxicity against the human myeloid leukemia cell line (HL-60). A linear glycosylation strategy allowed for accessing a variety of functionalization patterns at both the spirostanic and the saccharide moieties, which provides new information regarding the structure-cytotoxicity relationship of this family of steroidal glycosides. Intriguing results were achieved with respect to hecogenyl and 5 alpha-hydroxy-laxogenyl beta-chacotriosides, turning out to be the former very cytotoxic and the latter no cytotoxic at all. Importantly, the partially pivaloylated beta-D-glucosides of 5 alpha-hydroxy-laxogenin were the most potent cytotoxic compounds among all tested glycosides. This comprises the first report on acylated spirostanyl glucosides displaying significant cytotoxicity, and therefore, it opens up new opportunities toward the development of saponin analogues as anticancer agents. (C) 2012 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10553/50553
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2012.02.026
Source: Bioorganic & Medicinal Chemistry[ISSN 0968-0896],v. 20 (8), p. 2690-2700
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