Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/50552
Título: Cytotoxic sesquiterpene lactones and other constituents of centaurea omphalotricha
Autores/as: Kolli, El Hadj
León, Francisco
Benayache, Fadila
Estévez, Sara 
Quintana, Jose 
Estévez, Francisco 
Brouard Martín,Ignacio 
Bermejo, Jaime
Benayach, Samir
Clasificación UNESCO: 32 Ciencias médicas
3209 Farmacología
Palabras clave: Centaurea
Asteraceae,
Sesquiterpene lactones
Cytotoxic activity
HL-60
Fecha de publicación: 2012
Proyectos: Evaluación de Potenciales Compuestos Antileucémicos. 
Publicación seriada: Journal of the Brazilian Chemical Society 
Resumen: Phytochemical research of the aerial parts of Centaurea omphalotricha led to the isolation of three new sesquiterpene lactones, 4'-acetyl cynaropicrin, 4'-acetyl cebellin F and 15-acetyl dehydromelitensin, together with twelve known compounds, seven sesquiterpene lactones, two isoprenoids and three flavonoids. The structures of the new compounds were elucidated by means of extensive 1D and 2D NMR, and MS, and by comparison with reported data in the literature. The effect of sesquiterpene lactones on the viability of the human tumor cell lines HL-60 and U937 was also investigated and 3-acetyl cynaropicrin, and 4'-acetyl cynaropicrin were found to be the most cytotoxic compounds against human leukemia cells with an IC50 values of 2.0 +/- 0.9 and 5.1 +/- 0.4 mu mol L-1, respectively.
URI: http://hdl.handle.net/10553/50552
ISSN: 0103-5053
DOI: 10.1590/S0103-50532012000500026
Fuente: Journal of the Brazilian Chemical Society[ISSN 0103-5053],v. 23, p. 977-983
Colección:Artículos
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