Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50552
Title: Cytotoxic sesquiterpene lactones and other constituents of centaurea omphalotricha
Authors: Kolli, El Hadj
León, Francisco
Benayache, Fadila
Estévez, Sara 
Quintana, Jose 
Estévez, Francisco 
Brouard Martín,Ignacio 
Bermejo, Jaime
Benayach, Samir
UNESCO Clasification: 32 Ciencias médicas
3209 Farmacología
Keywords: Centaurea
Asteraceae,
Sesquiterpene lactones
Cytotoxic activity
HL-60
Issue Date: 2012
Project: Evaluación de Potenciales Compuestos Antileucémicos. 
Journal: Journal of the Brazilian Chemical Society 
Abstract: Phytochemical research of the aerial parts of Centaurea omphalotricha led to the isolation of three new sesquiterpene lactones, 4'-acetyl cynaropicrin, 4'-acetyl cebellin F and 15-acetyl dehydromelitensin, together with twelve known compounds, seven sesquiterpene lactones, two isoprenoids and three flavonoids. The structures of the new compounds were elucidated by means of extensive 1D and 2D NMR, and MS, and by comparison with reported data in the literature. The effect of sesquiterpene lactones on the viability of the human tumor cell lines HL-60 and U937 was also investigated and 3-acetyl cynaropicrin, and 4'-acetyl cynaropicrin were found to be the most cytotoxic compounds against human leukemia cells with an IC50 values of 2.0 +/- 0.9 and 5.1 +/- 0.4 mu mol L-1, respectively.
URI: http://hdl.handle.net/10553/50552
ISSN: 0103-5053
DOI: 10.1590/S0103-50532012000500026
Source: Journal of the Brazilian Chemical Society[ISSN 0103-5053],v. 23, p. 977-983
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