Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/50552
Título: | Cytotoxic sesquiterpene lactones and other constituents of centaurea omphalotricha | Autores/as: | Kolli, El Hadj León, Francisco Benayache, Fadila Estévez, Sara Quintana, Jose Estévez, Francisco Brouard Martín,Ignacio Bermejo, Jaime Benayach, Samir |
Clasificación UNESCO: | 32 Ciencias médicas 3209 Farmacología |
Palabras clave: | Centaurea Asteraceae, Sesquiterpene lactones Cytotoxic activity HL-60 |
Fecha de publicación: | 2012 | Proyectos: | Evaluación de Potenciales Compuestos Antileucémicos. | Publicación seriada: | Journal of the Brazilian Chemical Society | Resumen: | Phytochemical research of the aerial parts of Centaurea omphalotricha led to the isolation of three new sesquiterpene lactones, 4'-acetyl cynaropicrin, 4'-acetyl cebellin F and 15-acetyl dehydromelitensin, together with twelve known compounds, seven sesquiterpene lactones, two isoprenoids and three flavonoids. The structures of the new compounds were elucidated by means of extensive 1D and 2D NMR, and MS, and by comparison with reported data in the literature. The effect of sesquiterpene lactones on the viability of the human tumor cell lines HL-60 and U937 was also investigated and 3-acetyl cynaropicrin, and 4'-acetyl cynaropicrin were found to be the most cytotoxic compounds against human leukemia cells with an IC50 values of 2.0 +/- 0.9 and 5.1 +/- 0.4 mu mol L-1, respectively. | URI: | http://hdl.handle.net/10553/50552 | ISSN: | 0103-5053 | DOI: | 10.1590/S0103-50532012000500026 | Fuente: | Journal of the Brazilian Chemical Society[ISSN 0103-5053],v. 23, p. 977-983 |
Colección: | Artículos |
Citas SCOPUSTM
42
actualizado el 08-dic-2024
Citas de WEB OF SCIENCETM
Citations
26
actualizado el 25-feb-2024
Visitas
52
actualizado el 30-dic-2023
Google ScholarTM
Verifica
Altmetric
Comparte
Exporta metadatos
Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.