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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50552
DC FieldValueLanguage
dc.contributor.authorKolli, El Hadjen_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorBenayache, Fadilaen_US
dc.contributor.authorEstévez, Saraen_US
dc.contributor.authorQuintana, Joseen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.authorBrouard Martín,Ignacioen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.authorBenayach, Samiren_US
dc.contributor.otherBrouard, Ignacio-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherLeon, Francisco-
dc.contributor.otherBenayache, Samir-
dc.contributor.otherBenayache, Fadila-
dc.date.accessioned2018-11-24T16:56:17Z-
dc.date.available2018-11-24T16:56:17Z-
dc.date.issued2012en_US
dc.identifier.issn0103-5053en_US
dc.identifier.urihttp://hdl.handle.net/10553/50552-
dc.description.abstractPhytochemical research of the aerial parts of Centaurea omphalotricha led to the isolation of three new sesquiterpene lactones, 4'-acetyl cynaropicrin, 4'-acetyl cebellin F and 15-acetyl dehydromelitensin, together with twelve known compounds, seven sesquiterpene lactones, two isoprenoids and three flavonoids. The structures of the new compounds were elucidated by means of extensive 1D and 2D NMR, and MS, and by comparison with reported data in the literature. The effect of sesquiterpene lactones on the viability of the human tumor cell lines HL-60 and U937 was also investigated and 3-acetyl cynaropicrin, and 4'-acetyl cynaropicrin were found to be the most cytotoxic compounds against human leukemia cells with an IC50 values of 2.0 +/- 0.9 and 5.1 +/- 0.4 mu mol L-1, respectively.en_US
dc.languageengen_US
dc.relationEvaluación de Potenciales Compuestos Antileucémicos.en_US
dc.relation.ispartofJournal of the Brazilian Chemical Societyen_US
dc.sourceJournal of the Brazilian Chemical Society[ISSN 0103-5053],v. 23, p. 977-983en_US
dc.subject32 Ciencias médicasen_US
dc.subject3209 Farmacologíaen_US
dc.subject.otherCentaureaen_US
dc.subject.otherAsteraceae,en_US
dc.subject.otherSesquiterpene lactonesen_US
dc.subject.otherCytotoxic activityen_US
dc.subject.otherHL-60en_US
dc.titleCytotoxic sesquiterpene lactones and other constituents of centaurea omphalotrichaen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1590/S0103-50532012000500026en_US
dc.identifier.scopus84861169337-
dc.identifier.isi000304852800026-
dcterms.isPartOfJournal Of The Brazilian Chemical Society-
dcterms.sourceJournal Of The Brazilian Chemical Society[ISSN 0103-5053],v. 23 (5), p. 977-983-
dc.contributor.authorscopusid55220583800-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid6603336437-
dc.contributor.authorscopusid53867837200-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid6603470039-
dc.contributor.authorscopusid7101636723-
dc.contributor.authorscopusid55220092000-
dc.description.lastpage983en_US
dc.description.firstpage977en_US
dc.relation.volume23en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000304852800026-
dc.contributor.daisngid11905926-
dc.contributor.daisngid136703-
dc.contributor.daisngid461918-
dc.contributor.daisngid4613160-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.contributor.daisngid657275-
dc.contributor.daisngid5695465-
dc.contributor.daisngid447236-
dc.identifier.investigatorRIDK-5175-2014-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages7en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Kolli, E-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Benayache, F-
dc.contributor.wosstandardWOS:Estevez, S-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Brouard, I-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.contributor.wosstandardWOS:Benayache, S-
dc.date.coverdateMayo 2012en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr0,457-
dc.description.jcr1,283-
dc.description.sjrqQ2-
dc.description.jcrqQ3-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameBrouard Martín, Ignacio-
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