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Title: 5-Lipoxygenase pathway gene polymorphisms: Lack of association with asthma in a Spanish population
Authors: Torres-Galván, M. J.
Cumplido, J. A.
Buset, N.
Caballero-Hidalgo, A.
Blanco, C.
Hernández, E.
Carrillo, T. 
UNESCO Clasification: 32 Ciencias médicas
320701 Alergias
Keywords: Bronchial asthma
5-Lipoxygenase pathway
Issue Date: 2009
Journal: Journal of Investigational Allergology and Clinical Immunology 
Abstract: Background: Cysteinyl-leukotrienes are mediators of inflammatory responses in bronchial asthma. We studied the genes encoding the enzymes involved in their synthesis to identify risk factors for asthma. The promoter polymorphisms LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 have been reported to be associated with bronchial asthma. Methods: We analyzed the effects of LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 on asthma susceptibility by means of a case-control study with 193 ethnically matched, unrelated individuals. Participants were classified as severe asthmatics, nonsevere asthmatics, and nonasthmatics, using a combination of 2 techniques: polymerase chain reaction-restricted fragment length polymorphism and multiplex capillary electrophoresis. Results: No association was found between these polymorphisms and asthma, neither individually nor in combination. Conclusion: Although the studied polymorphisms have been previously reported to constitute risk factors for the disease, we found no association between LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 polymorphisms and bronchial asthma.
ISSN: 1018-9068
Source: Journal of Investigational Allergology and Clinical Immunology[ISSN 1018-9068],v. 19(6), p. 453-458
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