|Title:||Differences among pollen-allergic patients with and without plant food allergy||Authors:||Cuesta-Herranz, Javier
Crespo, Jesús F.
Florido, J. Fernando
Ibáñez, M. Dolores
Garcia, Blanca E.
Alonso Díaz De Durana, M. Dolores
Tabar, Ana I.
|UNESCO Clasification:||32 Ciencias médicas
Plant food allergy
Pru p 3
Profilin, et al
|Issue Date:||2010||Journal:||International Archives of Allergy and Immunology||Abstract:||Background: A considerable number of pollen-allergic patients develops allergy to plant foods, which has been attributed to cross-reactivity between food and pollen allergens. The aim of this study was to analyze the differences among pollen-allergic patients with and without plant food allergy. Methods: Eight hundred and six patients were recruited from 8 different hospitals. Each clinical research group included 100 patients (50 plant food-allergic patients and 50 pollen-allergic patients). Diagnosis of pollen allergy was based on typical case history of pollen allergy and positive skin prick tests. Diagnosis of plant-food allergy was based on clear history of plant-food allergy, skin prick tests and/or plant-food challenge tests. A panel of 28 purified allergens from pollens and/or plant foods was used to quantify specific IgE (ADVIA-Centaur® platform). Results: Six hundred and sixty eight patients (83%) of the 806 evaluated had pollen allergy: 396 patients with pollen allergy alone and 272 patients with associated food and pollen allergies. A comparison of both groups showed a statistically significant increase in the food and pollen allergy subgroup in frequency of: (1) asthma (47 vs. 59%; p < 0.001); (2) positive skin test results to several pollens: Plantago,Platanus,Artemisia,Betula,Parietaria and Salsola (p < 0.001); (3) sensitization to purified allergens: Pru p 3, profilin, Pla a 1 – Pla a 2, Sal k 1, PR-10 proteins and Len c 1. Conclusion: Results showed relevant and significant differences between both groups of pollen-allergic patients depending on whether or not they suffered from plant-derived food allergy.||URI:||http://hdl.handle.net/10553/50221||ISSN:||1018-2438||DOI:||10.1159/000312636||Source:||International Archives of Allergy and Immunology[ISSN 1018-2438],v. 153(2), p. 182-192 (Septiembre 2010)|
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