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Title: Measurement of asthma control according to global initiative for asthma guidelines: a comparison with the asthma control questionnaire
Authors: Olaguibel, José M.
Quirce, Santiago
Juliá, Berta
Fernández, Cristina
Fortuna, Ana M.
Molina, Jesús
Plaza, Vicente
Aguar, María
Agüero, Ramón
Aicart, Dolores
Almela, Teresa
Almonacid, Carlos
Alonso, Alicia
Álvarez, Francisco
Álvarez, Julio
Álvarez, María
Álvarez, Pedro
Amiama, Javier
Antepara, Ignacio
Armisen, Margarita
Arnedillo, Aurelio
Azpiazu, Mikel
Barrio, Javier
Bazús, Teresa
Bello, Dolores
Bentabol, Miguel
Beristain, Ana
Blanco, Carlos
Blanco, Rosa
Borderías, Luís
Bustamante, Ana
Caballero, Pedro
Cabrera, Pedro
Calero, Francisco
Calvo, Eduardo
Cantó, Gabriela
Cañete, Concepción
Carballada, Francisco
Cárdenas, Remedios
Carpintero, Manuel
Carretero, Pedro
Carrillo, Teresa 
Casado, María
Casas, Francisco
Cebollero, Pilar
Cisneros, Carolina
Clemente, Lourdes
Colas, Carlos
Compaired, José
Compte, Luis
Cordobés, Concepción
Dávila, Ignacio
De Diego, Alfredo
De Higes, Eva
De la Hoz, Belén
De León, Juan
Del Moral, Ángel
Delgado, Julio
Díaz, Carmen
Diego, Carlos
Domínguez, Carmen
Domínguez, Javier
Domínguez, Leopoldo
Entrenas, Luisma
Escobar, Miguel
Espigares, Manuel
Espinosa, María
Félix, Rubén
Feo, Francisco
Fernández, Araceli
Fernández, Consuelo
Fernández, Eduardo
Fernández, Francisco
Fernández, Mar
Figueroa, Javier
Flor, Xavier
García, Jesús
García, Jose
García, Juan
García, Marimar
García, Rosa
Gómez, Elisa
González, David
González, Francisco
González, Ruperto
Gutiérrez, Valentina
Henriquez, Aythamy
Hernández, Alicia
Hernández, Dolores
Hernández, Elena
Hernández, Francisco
Hidalgo, Eduardo
Ibañez, Paloma
Iglesias, Fernando
Iglesias, Javier
Ignacio, José
Irizar, María
Izquierdo, José
UNESCO Clasification: 32 Ciencias médicas
3205 Medicina interna
Keywords: Asthma control
GINA guidelines
Asthma control questionnaire
Validation study
Issue Date: 2012
Journal: Respiratory Research 
Abstract: Introduction Asthma Control Questionnaire (ACQ) is a validated tool to measure asthma control. Cut-off points that best discriminate “well-controlled” or “not well-controlled” asthma have been suggested from the analysis of a large randomized clinical trial but they may not be adequate for daily clinical practice. Aims To establish cut-off points of the ACQ that best discriminate the level of control according to Global Initiative for Asthma (GINA) 2006 guidelines in patients with asthma managed at Allergology and Pulmonology Departments as well as Primary Care Centers in Spain. Patients and methods An epidemiological descriptive study, with prospective data collection. Asthma control following GINA-2006 classification and 7-item ACQ was assessed. The study population was split in two parts: 2/3 for finding the cut-off points (development population) and 1/3 for validating the results (validation population). Results A total of 1,363 stable asthmatic patients were included (mean age 38 ± 14 years, 60.3% women; 69.1% non-smokers). Patient classification according to GINA-defined asthma control was: controlled 13.6%, partially controlled 34.2%, and uncontrolled 52.3%. The ACQ cut-off points that better agreed with GINA-defined asthma control categories were calculated using receiver operating curves (ROC). The analysis showed that ACQ < 0.5 was the optimal cut-off point for “controlled asthma” (sensitivity 74.1%, specificity 77.5%) and 1.00 for “uncontrolled asthma” (sensitivity 73%, specificity 88.2%). Kappa index between GINA categories and ACQ was 0.62 (p < 0.001). Conclusion The ACQ cut-off points associated with GINA-defined asthma control in a real-life setting were <0.5 for controlled asthma and ≥1 for uncontrolled asthma.
ISSN: 1465-9921
DOI: 10.1186/1465-9921-13-50
Source: Respiratory Research[ISSN 1465-9921],v. 13 (50) (Junio 2012)
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