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Title: Graph Based Study of Allergen Cross-Reactivity of Plant Lipid Transfer Proteins (LTPs) Using Microarray in a Multicenter Study
Authors: Palacín, Arantxa
Gómez-Casado, Cristina
Rivas, Luis A.
Aguirre, Jacobo
Tordesillas, Leticia
Bartra, Joan
Blanco, Carlos
Carrillo, Teresa 
Cuesta-Herranz, Javier
de Frutos, Consolación
Álvarez-Eire, Genoveva García
Fernández, Francisco J.
Gamboa, Pedro
Muñoz, Rosa
Sánchez-Monge, Rosa
Sirvent, Sofía
Torres, María J.
Varela-Losada, Susana
Rodríguez, Rosalía
Parro, Victor
Blanca, Miguel
Salcedo, Gabriel
Díaz-Perales, Araceli
UNESCO Clasification: 32 Ciencias médicas
320701 Alergias
Keywords: Allergens
Food allergies
Allergies, et al
Issue Date: 2012
Journal: PLoS ONE 
Abstract: The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0050799
Source: PLoS ONE [1932-6203],v. 7(12): e50799 (Diciembre 2012)
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