|Title:||Graph Based Study of Allergen Cross-Reactivity of Plant Lipid Transfer Proteins (LTPs) Using Microarray in a Multicenter Study||Authors:||Palacín, Arantxa
Rivas, Luis A.
de Frutos, Consolación
Álvarez-Eire, Genoveva García
Fernández, Francisco J.
Torres, María J.
|UNESCO Clasification:||32 Ciencias médicas
Allergies, et al
|Issue Date:||2012||Journal:||PLoS ONE||Abstract:||The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.||URI:||http://hdl.handle.net/10553/50215||ISSN:||1932-6203||DOI:||10.1371/journal.pone.0050799||Source:||PLoS ONE [1932-6203],v. 7(12): e50799 (Diciembre 2012)|
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