Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50003
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dc.contributor.authorCarrera, A. C.en_US
dc.contributor.authorCardenas, L.en_US
dc.contributor.authorTugores, A.en_US
dc.contributor.authorAlonso, M.en_US
dc.contributor.authorSanchez-Madrid, F.en_US
dc.contributor.authorDe Landazuri, M. O.en_US
dc.date.accessioned2018-11-24T12:28:36Z-
dc.date.available2018-11-24T12:28:36Z-
dc.date.issued1989en_US
dc.identifier.issn0021-9258en_US
dc.identifier.urihttp://hdl.handle.net/10553/50003-
dc.description.abstractActivation of human T cells through the CD3-T cell receptor complex caused an augmentation in the cell surface expression of CD2 and CD5 glycoproteins. Evidence that protein kinase C is involved in the up-regulatory mechanism of these cell surface molecules has been obtained by three different approaches: (a) the changes in antigen expression were observed with activators of protein kinase C such as phorbol esters but not with activators of kinases dependent on calcium/calmodulin or cAMP; (b) the overexpression of CD2 and CD5 is also observed in cells treated with 1,2-dioctanoyl-rac-glycerol, an analogue of the physiological activator of protein kinase C; and (c) 1-(5-isoquinolinyl)-2-methylpiperazine, an inhibitor of protein kinase C but not N-(2-guanidinoethyl)-5-isoquinolinesulfonamide dihydrochloride, an inhibitor of the cAMP-dependent kinase, impairs CD2 and CD5 up-regulation. These changes in cell surface antigen expression appear to be caused by the concomitant increase in the mRNA levels for CD2 and CD5. Phosphorylation studies of the CD2 and CD5 glycoproteins indicated that the overexpression of these molecules was not associated with a specific pattern of phosphorylation since it was observed independently of their hyperphosphorylated or nonphosphorylated state.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Biological Chemistryen_US
dc.sourceJournal of Biological Chemistry[ISSN 0021-9258],v. 264, p. 15650-15655 (Marzo 1989)en_US
dc.subject32 Ciencias médicasen_US
dc.subject2302 Bioquímicaen_US
dc.subject.otherProtein kinase Cen_US
dc.subject.otherCell surface expressionen_US
dc.subject.otherGlycoproteinsen_US
dc.titleActivators of protein kinase C up-regulate the cell surface expression of CD2 and CD5 T cell glycoproteinsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.scopus0024442946-
dc.contributor.authorscopusid7006396921-
dc.contributor.authorscopusid7004368553-
dc.contributor.authorscopusid6701671839-
dc.contributor.authorscopusid7401661849-
dc.contributor.authorscopusid7102563014-
dc.contributor.authorscopusid7006816026-
dc.description.lastpage15655en_US
dc.description.firstpage15650en_US
dc.relation.volume264en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.date.coverdateMarzo 1989en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-1849-9239-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameTugores Céster,Antonio-
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