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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49974
DC FieldValueLanguage
dc.contributor.authorDel Mar Tavío, Maríaen_US
dc.contributor.authorVila, Jordien_US
dc.contributor.authorRuiz, Joaquímen_US
dc.contributor.authorMartín Sánchez, Antonio Manuelen_US
dc.contributor.authorJiménez De Anta, María Teresaen_US
dc.date.accessioned2018-11-24T12:14:46Z-
dc.date.available2018-11-24T12:14:46Z-
dc.date.issued2000en_US
dc.identifier.issn0924-8579en_US
dc.identifier.urihttp://hdl.handle.net/10553/49974-
dc.description.abstractFive quinolone-resistant strains were developed from a clinical Morganella morganii isolate (M1 strain) which was susceptible to nalidixic acid and fluoroquinolones. All five in vitro selected mutants showed diminished norfloxacin accumulation and two of them also decreased the expression of the Ago in the outer membrane lipopolysaccharide with respect to their parent strain and to the M. morganii NCTC-235 type strain. Likewise, the M1 strain did not express a 37-38 kDa protein and accumulated less norfloxacin than the M. morganii NCTC-235 strain. The decreased norfloxacin uptake in the five mutants compared with the M. morganii NCTC-235 strain was due to an enhanced proton-dependent active efflux plus a pre-existent decreased expression of a 37-38 kDa protein in the parent strain.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Antimicrobial Agentsen_US
dc.sourceInternational Journal of Antimicrobial Agents[ISSN 0924-8579],v. 14(2), p. 157-160 (Marzo 2000)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320103 Microbiología clínicaen_US
dc.subject.otherQuinolonesen_US
dc.subject.otherResistanceen_US
dc.subject.otherPermeabilityen_US
dc.subject.otherActive-effluxen_US
dc.subject.otherMorganella morganiien_US
dc.titleDecreased permeability and enhanced proton-dependent active efflux in the development of resistance to quinolones in Morganella morganiien_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0924-8579(00)00117-5en_US
dc.identifier.scopus0034099126-
dc.identifier.isi000086127400011-
dc.contributor.authorscopusid6701659492-
dc.contributor.authorscopusid7202012753-
dc.contributor.authorscopusid35392400000-
dc.contributor.authorscopusid6505747527-
dc.contributor.authorscopusid6506989655-
dc.description.lastpage160en_US
dc.description.firstpage157en_US
dc.relation.volume14en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid9058102-
dc.contributor.daisngid24031-
dc.contributor.daisngid173728-
dc.contributor.daisngid9668653-
dc.contributor.daisngid459288-
dc.description.numberofpages4en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Tavio, MD-
dc.contributor.wosstandardWOS:Vila, J-
dc.contributor.wosstandardWOS:Ruiz, J-
dc.contributor.wosstandardWOS:Sanchez, AMM-
dc.contributor.wosstandardWOS:de Anta, MTJ-
dc.date.coverdateMarzo 2000en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,141-
dc.description.jcrqQ3-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR Investigación Básica y Aplicada en Ciencias de la Salud-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-1808-7461-
crisitem.author.parentorgDepartamento de Ciencias Clínicas-
crisitem.author.fullNameTavío Pérez, María Del Mar-
crisitem.author.fullNameMartín Sánchez, Antonio Manuel-
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