Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49963
Title: QnrB9 in association with TEM-116 extended-spectrum beta-lactamase in Citrobacter freundii isolated from sewage effluent: First report from Italy
Authors: Forcella, C.
Pellegrini, C.
Celenza, G.
Segatore, B.
Calabrese, R.
Tavío, M. M. 
Amicosante, G.
Perilli, Mariagrazia
Keywords: Mediated Quinolone Resistance
Molecular Characterization
Nationwide Survey
Plasmid
Gene, et al
Issue Date: 2010
Publisher: 1120-009X
Journal: Journal of Chemotherapy 
Abstract: The aim of the present study was to investigate the mechanism of quinolone and beta-lactam resistance in an isolate of Citrobacter freundii PC2/08 collected from sewage effluent from L'Aquila, Italy. qnrB-9 and bla(TEM-116) were co-expressed in a large plasmid identified in C. freundi PC2/08 strain. Compared to TEM-1, TEM-116 showed two single mutations: V84I and A184V. The pIPC2/08 plasmid conferred resistance to several beta-lactams and fluoroquinolones. Tazobactam could be considered a good inhibitor whereas clavulanic acid was unable to restore susceptibility to amoxicillin. The QnrB-9 element seems to confer the same level of resistance to levofloxacin and ciprofloxacin with minimum inhibitory concentration (MIC) values of 4 mg/L for either. In this study, we confirm the common association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase (ES beta L) production. This is the first finding in Italy of qnrB9 and TEM-116 in a non-clinical or animal strain.
URI: http://hdl.handle.net/10553/49963
ISSN: 1120-009X
DOI: 10.1179/joc.2010.22.4.243
Source: Journal of Chemotherapy[ISSN 1120-009X],v. 22, p. 243-245
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