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Title: Estimated prevalence of chronic renal failure among patients with type 2 diabetes in Spain
Authors: de Pablos-Velasco, Pedro Luis 
Ampudia-Blasco, Francisco Javier
Cobos, Albert
Bergoñón, Salvador
Pedrianes, Pablo
UNESCO Clasification: 32 Ciencias médicas
320506 Nefrología
Keywords: Glomerular-Filtration-Rate
Chronic Kidney-Disease
Issue Date: 2010
Journal: Medicina Clínica 
Abstract: Background and objective: The aim of this study was to estimate the current prevalence of Chronic Renal Insufficiency (RI) in ambulatory patients with type 2 Diabetes (T2DM) assisted in Endocrinology Departments all over Spain.Patients and methods: This was an observational, cross sectional, multicenter study. From each participant the following data were retrospective collected: demographic, anthropometric, renal function, diabetes, cardiovascular risk factors, comorbidities and treatment. RI was defined by a glomerular filtration rate lower than 60 ml/min/1.73 m(2), using the shortened MDRD method.Results: 541 patients with T2DM were included, 53% were men, the mean age (DS) was 63 years old (7.9) and the HbA(1)C was 7.6 % (1.3). The prevalence (CI95%) of RI was 22.9% (19.4-26.7), higher than the previous estimate, witch was 5.7% (3.9-8.0, p < 0,0001). The associated risk factor for RI were age (OR 2.07; 95%CI: 1.47-2.91 per each ten year period of increase), female gender (OR 2.25: 95%CI: 1.36-3.71) and hyperuricemia (OR 3.15; 95% CI: 1.56-6.37). There were no differences in the metabolic control between patients with RI vs those without RI.Conclusions: 22.9% of T2DM ambulatory patients followed by endocrinologist had RI, but just a quarter of them had previously been diagnosed. The automated determination of creatinine clearance could increase the proportion of diagnosis and facilitate the improvement of the metabolic control in these patients.
ISSN: 0025-7753
DOI: 10.1016/j.medcli.2009.09.045
Source: Medicina Clinica[ISSN 0025-7753],v. 134, p. 340-345 (Marzo 2010)
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