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http://hdl.handle.net/10553/49502
| Título: | Effect of fat feeding on human intestinal apolipoprotein B mRNA levels and editing | Autores/as: | Lopez-Miranda, Jose Kam, Nathan Osada, Jesus Rodriguez, Carmen Fernandez, Pilar Contois, John Schaefer, Ernst J. Ordovas, Jose M. |
Clasificación UNESCO: | 32 Ciencias médicas 2302 Bioquímica |
Palabras clave: | Apolipoprotein Apolipoprotein B Intestine mRNA Postprandial |
Fecha de publicación: | 1994 | Publicación seriada: | Biochimica et biophysica acta. L, Lipids and lipid metabolism | Resumen: | Our purpose was to assess the effect of a fat-rich meal on intestinal apolipoprotein B (apoB) mRNA levels and editing. We obtained jejunal biopsies from eight healthy adults in the fasting state and 3 h after a meal containing 1 g/kg of fat. In the fasting state, 93% of the apoB mRNA contained the editing sequence resulting in apoB-48 production. Feeding induced no significant changes in apoB mRNA levels or editing. Our data are consistent with the concept that the significant increase in apoB-48 within triglyceride-rich lipoproteins in postprandial plasma is not due to alterations in apoB gene expression or editing. | URI: | http://hdl.handle.net/10553/49502 | ISSN: | 0005-2760 | DOI: | 10.1016/0005-2760(94)90038-8 | Fuente: | Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism[ISSN 0005-2760],v. 1214, p. 143-147 |
| Colección: | Artículos |
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