Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49385
Title: Carbohydrate metabolism changes in cystic fibrosis
Authors: Domínguez-García, Ángela
Quinteíro-González, Sofía
Peña-Quintana, Luis 
Ramos-Macias, Leticia
Quintana-Martel, Mercedes
Saavedra Santana, Pedro 
UNESCO Clasification: 32 Ciencias médicas
320110 Pediatría
320502 Endocrinología
Keywords: Impaired Glucose-Tolerance
Beta-Cell Dysfunction
Diabetes-Mellitus
Insulin Sensitivity
Clinical Status, et al
Issue Date: 2007
Journal: Journal of Pediatric Endocrinology and Metabolism 
Abstract: Aims: To assess the prevalence of impaired glucose tolerance (ITG) and diabetes mellitus (DMRCF) in a group of patients with cystic fibrosis (CF). To study clinical status-related variables and to compare age with the evolution of their carbohydrate metabolism (CHM).Patients and Methods: Thirty patients with CF (1.5-26 years). Oral glucose tolerance test (OGTT) in 28 patients.Results: Three patients (10%) showed ITG and four DMRCF (13.3%). CF patients with impaired CHM (ICHM) were older (p = 0.006), and had longer times since diagnosis and first sputum colonization (p = 0.001, p < 0.001). Homozygous delta F508 mutation was significant (p = 0.001). Insulin peak, area under the curve for insulin, insulin resistance, insulin sensitivity, and pancreatic beta-cell function were all significant.Conclusions: ICHM was present in 23.3%. Age, time since diagnosis of CF, first sputum colonization and homozygous delta F508 mutation were significantly associated. CHM in patients with CF is similar to that in the population without CF in the early years.
URI: http://hdl.handle.net/10553/49385
ISSN: 0334-018X
DOI: 10.1515/JPEM.2007.20.5.621
Source: Journal of Pediatric Endocrinology and Metabolism[ISSN 0334-018X],v. 20, p. 621-632 (Enero 2007)
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