Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/49370
Título: Manifestations and evolution of wilson disease in pediatric patients carrying ATP7B mutation L708P
Autores/as: Peña-Quintana, Luis 
García-Luzardo, María R.
García-Villarreal, Luis
Arias-Santos, María D.
Garay Sanchez, Paloma 
Santana, Alfredo 
González-Santana, Daniel
Ramos-Varela, Juan C.
Rial-González, Ramiro
Tugores, Antonio 
Clasificación UNESCO: 32 Ciencias médicas
320110 Pediatría
320503 Gastroenterología
Palabras clave: Copper Transporting Atpase
P-Type Atpase
Liver-Transplantation
Menkes Disease
Gene, et al.
Fecha de publicación: 2012
Publicación seriada: Journal of Pediatric Gastroenterology and Nutrition 
Resumen: Objectives: The aim of the study was to characterize a group of 11 pediatric patients, ages 3 to 13 years, affected by Wilson disease (WD) in the island of Gran Canaria, Spain.Patients and Methods: Genetic, biochemical, and pathological features, together with their response to treatment and clinical evolution, have been analyzed for this group of patients.Results: Genetically, the group was rather homogeneous, with an extremely high prevalence of the L708P mutation (4 homozygotes and 5 heterozygotes). Despite being initially screened because of asymptomatic hypertransaminemia, all of the patients presented with some degree of liver damage that was never accompanied by any neurological manifestation. Hepatic damage was most severe in a compound heterozygote with a novel mutation, G1266W, affecting a motif in the ATP7B polypeptide that is greatly conserved in similar proteins among metazoans. Ceruloplasmin and copper serum levels, together with the determination of hepatic copper content, were found to be of great diagnostic value, whereas urine copper measurements were found to be much less conclusive. All of the patients responded well to treatment with D-penicillamine with no documented adverse reactions.Conclusions: The patients in Gran Canaria constitute, overall, one of the largest groups of patients with WD with a high incidence of a single mutation, allowing us to define the early clinical symptoms and the evolution of the disease in patients carrying the ATP7B L708P mutant allele, and the study of WD in a genetically homogeneous background.
URI: http://hdl.handle.net/10553/49370
ISSN: 0277-2116
DOI: 10.1097/MPG.0b013e318230130c
Fuente: Journal of Pediatric Gastroenterology and Nutrition[ISSN 0277-2116],v. 54, p. 48-54 (Enero 2012)
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