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Title: Spanish National Registry of Celiac Disease: Incidence and clinical presentation
Authors: Cilleruelo, Ma Luz
Roman-Riechmann, Enriqueta
Sanchez-Valverde, Felix
Donat, Ester
Manuel-Ramos, Jose
Martín-Orte, Emilio
López, Maria Jose
García-Novo, Dolores
García, Salvador
Pavón, Pilar
Martín, Manuel
Ortigosa, Luis
Barrio, Josefa
Gutierrez, Carolina
Espin, Beatriz
Castillejo, Gemma
Peña-Quintana, Luis 
Hualde, Idoia
Sebastián, Mercedes
Calvo, Carmen
Fernández, Sonia
De Manueles, Julio
Armas, Honorio
Urruzuno-Tellerias, Pedro
Juste, Mercedes
Bousoño, Carlos
Ribes-Koninckx, Carmen
UNESCO Clasification: 32 Ciencias médicas
320503 Gastroenterología
Keywords: Celiac disease
Issue Date: 2014
Journal: Journal of Pediatric Gastroenterology and Nutrition 
Abstract: Objectives The aim of this study was to assess the incidence and clinical pattern of celiac disease (CD) presently diagnosed in Spanish children. Methods A prospective, multicenter, nationwide registry of new cases of CD in children <15 years was conducted from June 1, 2006 to May 31, 2007. The parameters studied were age at diagnosis, sex, clinical symptoms, associated diseases, nutritional status, CD serology, histological lesions, and HLA-DQ2/-DQ8. The crude incidence rate of CD was calculated as new cases per 1000 live births and as new cases per 100,000 person-years <15 years of age. Results A total of 974 new cases of CD were included. The median age at diagnosis was 2.3 years; 39.5% of CD diagnoses occurred in the first 2 years, 42% between 2 and 6, and 18.4% from 6 to 15. Total number of cases in each age group was 385, 409, and 180, respectively. Regarding clinical presentation 70.9% showed classical symptoms, 21.9% were nonclassical, and 7% were asymptomatic. A total of 95.7% of 931, 94.7% of 611, and 86.7% of 651 children tested positive, respectively, for immunoglobulin A (IgA) anti-transglutaminase type 2 antibodies, IgA endomysial antibodies, and IgA anti-gliadin antibodies. Villous atrophy was observed in 92.4% and increased intraepithelial lymphocytes with crypt hyperplasia in 3.3%. Of the children, 55% had normal growth, and 3.4% were overweight. The HLA phenotype was DQ2: 88.3%, DQ2/DQ8: 8.4%, and DQ8: 2.3%. The incidence rate was 7.9 cases of CD per 1000 live births and 54 cases per 100,000 person-years. Conclusions In Spain, the most frequent clinical presentation of CD is the classical form, mainly diagnosed during the first 2 years of life. The observed incidence of CD in Spanish children is much higher than the present CD incidence rates observed in other European countries.
ISSN: 0277-2116
DOI: 10.1097/MPG.0000000000000446
Source: Journal of Pediatric Gastroenterology and Nutrition[ISSN 0277-2116],v. 59(4), p. 522-526 (Octubre 2014)
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