|Title:||Effects of maternal ω-3 supplementation on fatty acids and on visual and cognitive development||Authors:||Hurtado, Jose A.
Premature-Infants, et al
|Issue Date:||2015||Publisher:||0277-2116||Journal:||Journal of Pediatric Gastroenterology and Nutrition||Abstract:||Objectives: The aim of the present study was to elucidate whether a dairy drink enriched with omega-3 long-chain polyunsaturated fatty acid (LC-PUFA) could have an impact on the lipid profile of the mother and the newborn, and also whether this intervention could affect the newborns' visual and cognitive development.Methods: A total of 110 pregnant women were randomly assigned to one of the following intervention groups: control group (n = 54), taking 400 mL/day of the control dairy drink, and supplemented group (fish oil [FO]) (n = 56), taking 400 mL/day of the fish oil-enriched dairy drink (including similar to 400 mg eicosapentaenoic acid-docosahexaenoic acid [DHA]/day). During the study, the mothers' diets were supervised by a nutritionist to encourage compliance with present recommendations of FA intake. Blood fatty acid profiles were determined in the mother's (at enrollment, at delivery, and at 2.5 and 4 months) and newborn (at delivery and at 2.5 months) placenta and breast milk (colostrum and at 1, 2, and 4 months). Pattern reversal visual evoked potentials (VEPs) (at 2.5 and 7.5 months) and Bayley test (at 12 months) were recorded.Results: DHA percentage was higher in plasma, erythrocyte membranes, and breast milk samples from the FO group. The ratio of nervonic acid was also higher in plasma and erythrocyte lipids of the mother and newborn's blood samples from the FO group. No differences were observed in the Bayley test. No differences were observed in VEPs between both groups. We observed a shorter latency, however, in the lower visual angle (7.5') in the boys of the supplemented group.Conclusions: Omega-3 LC-PUFA dietary supplement during pregnancy and lactation influenced the mother and newborn's fatty acid profile and nervonic acid content but did not show effects on visual and cognitive/psychomotor development.||URI:||http://hdl.handle.net/10553/49358||ISSN:||0277-2116||DOI:||10.1097/MPG.0000000000000864||Source:||Journal of Pediatric Gastroenterology and Nutrition[ISSN 0277-2116],v. 61, p. 472-480|
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