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Title: Selection of resistant subpopulations after in vitro exposure to gentamicin, tobramycin and amikacin in clinical isolates of Enterobacteriaceae
Authors: Rodriguez Esparragon, F. J. 
Moreno Roque, J. L.
Tejedor Junco, M. T. 
Gonzalez-Martin, M. 
Torres Garcia, M. M. 
Gonzalez-Lama, Z.
Issue Date: 1993
Publisher: 0214-3429
Journal: Revista Espanola de Quimioterapia 
Abstract: In an attempt to select subpopulations of aminoglycoside resistant strains, 108 isolates of Enterobacteriaceae were subjected to serial passages in the presence of increasing concentrations of these agents. Agar plates containing gentamicin (GM), tobramycin (TM) and amikacin (AMK) were employed. We found that only 30 strains exhibited an increase in the minimal inhibitory concentrations (MICs) of all aminoglycosides tested resulting in resistance to these antibiotics.
ISSN: 0214-3429
Source: Revista Espanola de Quimioterapia[ISSN 0214-3429],v. 6, p. 304-308
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