Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49333
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dc.contributor.authorRodriguez-Esparragon, FJ
dc.contributor.authorRodriguez-Perez, JC
dc.contributor.authorMacías-Reyes, Antonio
dc.contributor.authorAlamo-Santana, Fayna
dc.contributor.otherRodriguez-Esparragon, Francisco
dc.contributor.otherRodriguez-Perez, J.C.
dc.date.accessioned2018-11-24T06:20:27Z-
dc.date.available2018-11-24T06:20:27Z-
dc.date.issued2003
dc.identifier.issn0263-6352
dc.identifier.urihttp://hdl.handle.net/10553/49333-
dc.description.abstractObjective Peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) belongs to the family of the nuclear hormone receptors and has been recently implicated in vascular biology. PPARgamma2(Pro12Ala) gene polymorphism is associated with obesity, body mass index and diabetes mellitus. The endothelial nitric oxide synthase (eNOS) (4a/b) gene polymorphism contributes to coronary heart disease and hypertension risk. We tested whether both polymorphic variants were associated with hypertension risk, and their inter-relationship with plasma homocysteine.Design A case-control study was conducted selecting 235 subjects with arterial hypertension and 223 normotensive matched controls.Methods Genotyping for the PPARgamma2(Pro12Ala) and the eNOS(4a/b) were performed by mutagenically separated polymerase chain reaction and by polymerase chain reaction. Glucose, lipid profile, plasma creatinine, homocysteine and microalbuminuria were measured.Results We found a significant contribution of the PPARgamma2(Pro12Ala) and eNOS(4a/b) gene polymorphisms to hypertensive risk in our population (odds ratio, 1.9 and 1.6, respectively), confirmed by multiple logistic regression analysis. Those subjects with normal plasma homocysteine values had an increased hypertensive risk with an odds ratio of 2.6 for the PP genotype of the PPARgamma2 gene and an odds ratio of 1.8 for the a allele of the eNOS gene.Conclusions Both analyzed polymorphisms were associated in a synergistic manner with hypertension. This effect manifested only in those subjects with normal homocysteine plasma values. Our findings suggest complex genotype-environmental interactions on hypertensive risk. (C) 2003 Lippincott Williams Wilkins.
dc.publisher0263-6352
dc.relation.ispartofJournal of Hypertension
dc.sourceJournal Of Hypertension[ISSN 0263-6352],v. 21 (9), p. 1649-1655
dc.subject.otherSmooth-Muscle-Cells
dc.subject.otherReceptor-Gamma
dc.subject.otherPpar-Gamma
dc.subject.otherPro12Ala Polymorphism
dc.subject.otherPlasma Homocysteine
dc.subject.otherInsulin Sensitivity
dc.subject.otherBlood-Pressure
dc.subject.otherExpression
dc.subject.otherRisk
dc.subject.otherDisease
dc.titlePeroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are associated with essential hypertension
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1097/00004872-200309000-00013
dc.identifier.scopus0042733636
dc.identifier.isi000185147800013
dcterms.isPartOfJournal Of Hypertension
dcterms.sourceJournal Of Hypertension[ISSN 0263-6352],v. 21 (9), p. 1649-1655
dc.contributor.authorscopusid6603262370
dc.contributor.authorscopusid7005446255
dc.contributor.authorscopusid8311692000
dc.contributor.authorscopusid6602250906
dc.description.lastpage1655
dc.description.firstpage1649
dc.relation.volume21
dc.type2Artículoes
dc.identifier.wosWOS:000185147800013
dc.contributor.daisngid1305938
dc.contributor.daisngid245684
dc.contributor.daisngid5867264
dc.contributor.daisngid13171094
dc.identifier.investigatorRIDD-2810-2013
dc.identifier.investigatorRIDC-1247-2010
dc.contributor.wosstandardWOS:Rodriguez-Esparragon, FJ
dc.contributor.wosstandardWOS:Rodriguez-Perez, JC
dc.contributor.wosstandardWOS:Macias-Reyes, A
dc.contributor.wosstandardWOS:Alamo-Santana, F
dc.date.coverdateSeptiembre 2003
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptPatología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-1663-3673-
crisitem.author.orcid0000-0003-0023-1063-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Esparragón, Francisco Javier-
crisitem.author.fullNameRodríguez Pérez, José Carlos-
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