Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49333
DC FieldValueLanguage
dc.contributor.authorRodriguez-Esparragon, FJen_US
dc.contributor.authorRodriguez-Perez, JCen_US
dc.contributor.authorMacías-Reyes, Antonioen_US
dc.contributor.authorAlamo-Santana, Faynaen_US
dc.contributor.otherRodriguez-Esparragon, Francisco-
dc.contributor.otherRodriguez-Perez, J.C.-
dc.date.accessioned2018-11-24T06:20:27Z-
dc.date.available2018-11-24T06:20:27Z-
dc.date.issued2003en_US
dc.identifier.issn0263-6352en_US
dc.identifier.urihttp://hdl.handle.net/10553/49333-
dc.description.abstractObjective Peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) belongs to the family of the nuclear hormone receptors and has been recently implicated in vascular biology. PPARgamma2(Pro12Ala) gene polymorphism is associated with obesity, body mass index and diabetes mellitus. The endothelial nitric oxide synthase (eNOS) (4a/b) gene polymorphism contributes to coronary heart disease and hypertension risk. We tested whether both polymorphic variants were associated with hypertension risk, and their inter-relationship with plasma homocysteine.Design A case-control study was conducted selecting 235 subjects with arterial hypertension and 223 normotensive matched controls.Methods Genotyping for the PPARgamma2(Pro12Ala) and the eNOS(4a/b) were performed by mutagenically separated polymerase chain reaction and by polymerase chain reaction. Glucose, lipid profile, plasma creatinine, homocysteine and microalbuminuria were measured.Results We found a significant contribution of the PPARgamma2(Pro12Ala) and eNOS(4a/b) gene polymorphisms to hypertensive risk in our population (odds ratio, 1.9 and 1.6, respectively), confirmed by multiple logistic regression analysis. Those subjects with normal plasma homocysteine values had an increased hypertensive risk with an odds ratio of 2.6 for the PP genotype of the PPARgamma2 gene and an odds ratio of 1.8 for the a allele of the eNOS gene.Conclusions Both analyzed polymorphisms were associated in a synergistic manner with hypertension. This effect manifested only in those subjects with normal homocysteine plasma values. Our findings suggest complex genotype-environmental interactions on hypertensive risk.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Hypertensionen_US
dc.sourceJournal Of Hypertension[ISSN 0263-6352],v. 21 (9), p. 1649-1655en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherSmooth-Muscle-Cellsen_US
dc.subject.otherReceptor-Gammaen_US
dc.subject.otherPpar-Gammaen_US
dc.subject.otherPro12Ala Polymorphismen_US
dc.subject.otherPlasma Homocysteineen_US
dc.subject.otherInsulin Sensitivityen_US
dc.subject.otherBlood-Pressureen_US
dc.subject.otherExpressionen_US
dc.subject.otherRisken_US
dc.subject.otherDiseaseen_US
dc.titlePeroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are associated with essential hypertensionen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1097/00004872-200309000-00013en_US
dc.identifier.scopus0042733636-
dc.identifier.isi000185147800013-
dcterms.isPartOfJournal Of Hypertension-
dcterms.sourceJournal Of Hypertension[ISSN 0263-6352],v. 21 (9), p. 1649-1655-
dc.contributor.authorscopusid6603262370-
dc.contributor.authorscopusid7005446255-
dc.contributor.authorscopusid8311692000-
dc.contributor.authorscopusid6602250906-
dc.description.lastpage1655en_US
dc.description.firstpage1649en_US
dc.relation.volume21en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000185147800013-
dc.contributor.daisngid1305938-
dc.contributor.daisngid245684-
dc.contributor.daisngid5867264-
dc.contributor.daisngid13171094-
dc.identifier.investigatorRIDD-2810-2013-
dc.identifier.investigatorRIDC-1247-2010-
dc.description.numberofpages7en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Rodriguez-Esparragon, FJ-
dc.contributor.wosstandardWOS:Rodriguez-Perez, JC-
dc.contributor.wosstandardWOS:Macias-Reyes, A-
dc.contributor.wosstandardWOS:Alamo-Santana, F-
dc.date.coverdateSeptiembre 2003en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr3,572-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0003-1663-3673-
crisitem.author.orcid0000-0003-0023-1063-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Esparragón,Francisco Javier-
crisitem.author.fullNameRodríguez Pérez,José Carlos-
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