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Title: Arterial blood pressure variations: Homocysteine and nitric oxide synthase gene polymorphisms (NOS3)
Authors: Rodríguez Esparragón, F. J. 
Rodríguez Pérez, José Carlos 
Macías, A.
Hernández Trujillo, Y.
González Leiza, M.
Caballero, A.
Keywords: Coronary-Heart-Disease
Endothelial Dysfunction
Hyperhomocysteinemia, et al
Issue Date: 2006
Publisher: 0211-6995
Journal: Nefrologia 
Abstract: Background: The nitric oxide synthase (NOS3) C894T gene polymorphism seems as a genetic determinant of total homocysteine (tHcy) concentrations through an effect on folate catabolism. We tested for a significant contribution to blood pressure values for the NOS3 C894T and 4a/b gene polymorphisms and whether those changes could explain the modulating effect on tHcy concentrations.Patients and methods: We analyzed 158 healthy men. The NOS3 gene polymorphisms were determined by polymerase chain reaction (PCR) and restriction fragment analysis (G894T) and by PCR (4alb). Total homocysteine concentrations were evaluated by the fluorescence polarization immunoassay method.Results: In our population we did not obtain a significant contribution of the C894T to blood pressure variations. However, tHcy mean concentration values differed according C894T genotypes (P = 0.07). Interestingly, we did not obtain a significant modulating effect on tHcy concentrations according to 4alb genotypes although the 4alb genotype distribution was statistically associated with blood pressure variations.Conclusion: Our results showed a modulating effect of the NOS3 4alb gene variant on tHcy concentrations that is at least partially provoked by discrete blood pressure increments. Nevertheless, our multivariate analysis did not show a statistical significant role for the NOS3 G894T gene polymorphism on tHcy concentrations.
ISSN: 0211-6995
Source: Nefrologia[ISSN 0211-6995],v. 26, p. 559-563
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