Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/49318
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Rodriguez-Esparragon, Francisco | en_US |
dc.contributor.author | Serna-Gómez, Jaime Alberto | en_US |
dc.contributor.author | Hernández-Velázquez, Érika | en_US |
dc.contributor.author | Buset-Ríos, Nisa | en_US |
dc.contributor.author | Hernández-Trujillo, Yaridé | en_US |
dc.contributor.author | García-Bello, Miguel A. | en_US |
dc.contributor.author | Rodriguez-Perez, Jose C. | en_US |
dc.contributor.other | Rodriguez-Esparragon, Francisco | - |
dc.contributor.other | Rodriguez-Perez, J.C. | - |
dc.contributor.other | Garcia-Bello, Miguel-Angel | - |
dc.date.accessioned | 2018-11-24T06:12:53Z | - |
dc.date.available | 2018-11-24T06:12:53Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.issn | 0300-8177 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/49318 | - |
dc.description.abstract | The resistance of internal mammary artery (IMA) toward atherosclerosis is not well understood. In plasma, homocysteine (Hcy) occurs in reduced, oxidized, homocysteine thiolactone and a component of proteins as a result of N- or S-homocysteinylation. We evaluated S/N-homocysteinylated protein levels in IMA fragments of patients undergoing coronary artery bypass grafting, and whether they were affected by genetic common variants. We tested whether tHcy, Hcy-S-protein levels, genotypes or Hcy-induced methylation modifications were related to differences in iNOS, Ddah2, and eNOS gene expression between territories. A small percentage of Hcy-S-proteins were found in IMA fragments. The Mthfr C677T (rs1801133) and Pon-1 Leu55Met (rs854560) variants were associated with Hcy-S-proteins. We observed a gradual difference according to Hcy-S-protein levels in the methylation degree of the Ddah2 gene promoter in aortic, but not in IMA, fragments. No correlation between the degree of methylation and the Ddah2 gene expression levels was found in both types of analyzed fragments. Total Hcy but not Hcy-S-proteins correlated with iNOS promoter methylation. Analyzed variants seem to contribute to the in vivo Hcy binding properties to IMA. The contribution of the Hcy-derived methylation modifications to Ddah2 and eNOS gene expression seems to be tissue-specific and independent of the Ddah2/ADMA/eNOS pathway. Hcy-derived methylation modifications to the iNOS gene promoter contribute to a lesser extent to iNOS gene expression. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Molecular and Cellular Biochemistry | en_US |
dc.source | Molecular And Cellular Biochemistry[ISSN 0300-8177],v. 369 (1-2), p. 235-246 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 320102 Genética clínica | en_US |
dc.subject.other | Nitric-Oxide Synthase | en_US |
dc.subject.other | Methylenetetrahydrofolate Reductase | en_US |
dc.subject.other | Asymmetric Dimethylarginine | en_US |
dc.subject.other | Risk-Factor | en_US |
dc.subject.other | Endothelial-Cells | en_US |
dc.subject.other | Vascular-Disease | en_US |
dc.subject.other | Dna Methylation | en_US |
dc.subject.other | Gene | en_US |
dc.subject.other | Atherosclerosis | en_US |
dc.subject.other | Expression | en_US |
dc.title | Homocysteinylated protein levels in internal mammary artery (IMA) fragments and its genotype-dependence. S-Homocysteine-induced methylation modifications in IMA and aortic fragments | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s11010-012-1387-7 | en_US |
dc.identifier.scopus | 84865619653 | - |
dc.identifier.isi | 000308067100025 | - |
dcterms.isPartOf | Molecular And Cellular Biochemistry | - |
dcterms.source | Molecular And Cellular Biochemistry[ISSN 0300-8177],v. 369 (1-2), p. 235-246 | - |
dc.contributor.authorscopusid | 6603262370 | - |
dc.contributor.authorscopusid | 55308203100 | - |
dc.contributor.authorscopusid | 55348741300 | - |
dc.contributor.authorscopusid | 34970818700 | - |
dc.contributor.authorscopusid | 8758145300 | - |
dc.contributor.authorscopusid | 36099016000 | - |
dc.contributor.authorscopusid | 7005446255 | - |
dc.description.lastpage | 246 | en_US |
dc.description.firstpage | 235 | en_US |
dc.relation.volume | 369 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000308067100025 | - |
dc.contributor.daisngid | 1305938 | - |
dc.contributor.daisngid | 17118663 | - |
dc.contributor.daisngid | 13637672 | - |
dc.contributor.daisngid | 9299806 | - |
dc.contributor.daisngid | 5660229 | - |
dc.contributor.daisngid | 1700450 | - |
dc.contributor.daisngid | 245684 | - |
dc.identifier.investigatorRID | D-2810-2013 | - |
dc.identifier.investigatorRID | C-1247-2010 | - |
dc.identifier.investigatorRID | No ID | - |
dc.description.numberofpages | 12 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Rodriguez-Esparragon, F | - |
dc.contributor.wosstandard | WOS:Serna-Gomez, JA | - |
dc.contributor.wosstandard | WOS:Hernandez-Velazquez, E | - |
dc.contributor.wosstandard | WOS:Buset-Rios, N | - |
dc.contributor.wosstandard | WOS:Hernandez-Trujillo, Y | - |
dc.contributor.wosstandard | WOS:Garcia-Bello, MA | - |
dc.contributor.wosstandard | WOS:Rodriguez-Perez, JC | - |
dc.date.coverdate | Octubre 2012 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.sjr | 0,948 | - |
dc.description.jcr | 2,329 | - |
dc.description.sjrq | Q2 | - |
dc.description.jcrq | Q3 | - |
dc.description.scie | SCIE | - |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | GIR IUIBS: Patología y Tecnología médica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.orcid | 0000-0003-1663-3673 | - |
crisitem.author.orcid | 0000-0003-0023-1063 | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Rodríguez Esparragón,Francisco Javier | - |
crisitem.author.fullName | Rodríguez Pérez,José Carlos | - |
Colección: | Artículos |
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